#irak4

PF-05387252 CAS  1604034-71-0 C25H27N5O2 MW 429.51418 g/mol 2-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]-11H-indolo[3,2-c]quinoline-9-carbonitrile IRAK4 inhibitor Rheumatoid arthritis; SLE Preclinical In the past decade there has been considerable interest in targeting the innate immune system in the treatment of autoimmune diseases and sterile inflammation. Receptors of the innate immune…

PF-05388169 CAS 1604034-78-7,  MF C22 H21 N3 O4 MW 391.42 11H-Indolo[3,2-c]quinoline-9-carbonitrile, 2-methoxy-3-[2-(2-methoxyethoxy)ethoxy]- IRAK4 inhibitor Rheumatoid arthritis; SLE Preclinical PAPER Bioorganic & Medicinal Chemistry Letters (2014), 24(9), 2066-2072. http://www.sciencedirect.com/science/article/pii/S0960894X14002832 Identification and optimization of indolo[2,3-c]quinoline…

  PF-05388169

CAS 1604034-78-7,  MF C22 H21 N3 O4

MW 391.42

11H-​Indolo[3,​2-​c]​quinoline-​9-​carbonitrile, 2-​methoxy-​3-​[2-​(2-​methoxyethoxy)​ethoxy]​- IRAK4 inhibitor

Rheumatoid arthritis; SLE

Preclinical

      PAPER

Bioorganic & Medicinal Chemistry Letters (2014), 24(9), 2066-2072.

http://www.sciencedirect.com/science/article/pii/S0960894X14002832

Identification and optimization of…

  PF-05387252

CAS  1604034-71-0

C25H27N5O2 MW 429.51418 g/mol

2-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]-11H-indolo[3,2-c]quinoline-9-carbonitrile

IRAK4 inhibitor

Rheumatoid arthritis; SLE

Preclinical

In the past decade there has been considerable interest in targeting the innate immune system in the treatment of autoimmune diseases and sterile inflammation. Receptors of the innate…

PF-05387552 IRAK4 CAS 1604034-71-0 C25 H27 N5 O2 11H-​Indolo[3,​2-​c]​quinoline-​9-​carbonitrile, 2-​methoxy-​3-​[3-​(4-​methyl-​1-​piperazinyl)​propoxy]​- 2-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]-11H-indolo[3,2-c]quinoline-9-carbonitrile Molecular Weight429.51 Molecular Formula: C25H27N5O2 Molecular Weight: 429.51418 g/mol Synthesis PAPER Bioorganic & Medicinal Chemistry…

(2S)-2-hydroxy-3-[(3R)-12-{[(1r,4r)-4-(morpholin-4-yl)cyclohexyl]oxy}-7-thia-9,11-diazatricyclo[6.4.0.0²,⁶]dodeca-1(12),2(6),8,10-tetraen-3-yl]propanamide S)-2-hydroxy-3-((R)-4-(((lr,4R)-4-morpholinocyclohexyl)oxy)-6,7-dihydro-5H-cyclopenta [4,5] thieno [2,3-d] pyrimidin-5-yl)propanamide  CAS 1388896-07-8 C22 H30 N4 O4 S 5H-​Cyclopenta[4,​5]​thieno[2,​3-​d]​pyrimidine-​5-​propanamide,…

(2S)-2-hydroxy-3-[(3R)-12-{[(1r,4r)-4-(morpholin-4-yl)cyclohexyl]oxy}-7-thia-9,11-diazatricyclo[6.4.0.0²,⁶]dodeca-1(12),2(6),8,10-tetraen-3-yl]propanamide

ND 2158

IRAK4, 446.2

Company Nimbus Therapeutics LLC Description IL-1 receptor-associated kinase 4 (IRAK4) inhibitor Molecular Target Interleukin-1 receptor-associated kinase 4 (IRAK4) Mechanism of Action Interleukin-1…