#histopathological

In Wistar rats, cadmium toxicity caused damage and histopathological changes in the liver, kidneys, spleen and brain. The goal of this research was to investigate the possible protective effects of magnesium on tissue and organ histo-architectural integrity.

Forty male Wistar rats were randomly divided over 3 months into 4 groups: control group water, Cd group water and oral 15 mg/Kg CdCl2 dose, (Cd+Mg) group water and oral 15 mg/kg CdCl2+ 10 mg/kg MgCl2 dose, and Mg group water and oral 10 mg/kg MgCl2 dose, respectively.

In order to demonstrate the beneficial effect of magnesium treatment against chronic cadmium toxicity, a histopathological analysis was performed.

Cadmium administration for 3 months resulted in apparent histologic defects, liver, kidney, spleen and brain damage and alterations. In contrast to the Cadmium Group, magnesium supplementation showed substantial histological improvements and markedly reduced tissue damage.

The findings of this study indicate that the oral administration of magnesium in rats exposed to cadmium chronic toxicity improved the histopathological changes observed in the liver, kidney, spleen, and brain without any detectable histoarchitectural modification in the organs of rats supplemented with magnesium.

Toxicity by cadmium induced damages and histopathological changes in liver, kidneys, spleen and brain of Wistar rats. This research aimed at investigating the potential protective effects of magnesium on the histoarchitectural integrity of tissues and organs.

Forty male Wistar rats were randomly divided into 4 groups during 3 months: Control group received water, Cd group water and oral administration at dose 15 mg/Kg of CdCl2, (Cd+Mg) group water and oral administration at doses (15 mg / kg of CdCl2+ 10 mg/kg of MgCl2) and Mg group water and oral administration (10 mg/kg of MgCl2).

A histopahtological study was carried to show the beneficial effect of magnesium treatment against chronic cadmium toxicity.

Administration of cadmium for 3 months led to apparent histological abnormalities, damages and alterations to liver, kidney, spleen and brain. A supplementation of magnesium showed significant histological improvements and markedly reduced tissue damage when compared with Cadmium Group.

Results of this study demonstrate that the oral administration of magnesium in rats exposure to cadmium chronic toxicity ameliorated the histopathological changes observed in the liver, kidney, spleen and brain with no observable alteration in the histoarchitecture in the organs of the magnesium-supplemented rats.