Next Generation Sequencing Revolutionizes Genomics Research
In the late 20th century, Sanger sequencing emerged as the dominant method for determining DNA sequences. However, Sanger sequencing had limitations as it was expensive, time-consuming and could sequence only a small number of DNA fragments in parallel. This changed in the early 2000s with the development of new DNA sequencing platforms that enabled high-throughput or "next-generation" sequencing. Pioneering companies like 454 Life Sciences, Illumina, Applied Biosystems and Helicos developed technologies that could sequence millions of DNA fragments in parallel. This massively increased sequencing output and allowed sequencing entire genomes rapidly and at a fraction of the cost compared to Sanger sequencing.
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