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Bioinformatic Analysis Leads to Gene Combination that Makes Clinical Quality Mouse iPSCs

Adult cells can be de-differentiated so that they resemble embryonic stem cells by genetically engineering them to overexpress particular genes. Such reprogrammed cells are known as induced pluripotent stem cells or iPSCs, and these cells might have the potential to cure damaged nerves, regrow limbs and organs, and precisely model a patient’s particular disease. Unfortunately, the very process of…

Yale Scientists Find Marker for High-Quality Induced Pluripotent Stem Cells

Pluripotent stem cells can be made by genetically engineering adult cells into less mature cells that have pluripotency. These induced pluripotent stem cells or iPSCs can potentially differentiate into any cell type in the adult body and because they are made from the patient’s own cells, they have a lower risk of being rejected by the patient’s immune system.

However, iPSCs suffer from an…