#gepants

So I know gepants aren't supposed to cause rebound headaches the way triptans do. But I started taking every-other-day rimegepant, and it's like I get 24 hours of headachy-but-manageable (actually achieved some thesis writing this week!) followed by 24 hours of absolute-hell-on-earth.

Anyone else have similar experiences? And, if so, did it even out at some point?

Let’s talk about gepants. The FDA approved rimegepant, Nurtec ODT, for the prevention of future attacks. How does it work and how effective is it?

Dr. Tepper: In the rimegepant (Nurtec ODT) trials, the more that people took it, the less headache they had. This was the opposite of rebound or medication overuse headache. This suggested gepants could be used preventively, which would make sense since they block the CGRP from landing on a receptor. That can work acutely, but if you block the receptor daily, or every other day, you can prevent the CGRP from landing and causing migraine and thus have a preventive effect.

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Emphasis mine, but this is crazy!

Every other painkiller we take for migraine causes headaches if you use too much, ie, if you have chronic migraine and treat it every time