Marie Of Lorraine, also called Mary Of Guise/ Marie De Lorraine, or De Guise was born on November. 22nd, 1515 at Bar-le-Duc, Lorraine, France.
The daughter of Claude of Lorraine, Duc de Guise and Antoinette of Bourbon, Marie first married Louis D'Orleans, duc de Longueville in 1534, by whom she had two sons. After the duc's death in 1537, she was pursued for marriage by Henry VIII and James V, allegedly refusing Henry VIII's proposal by saying "I fear my neck is too small."
She wed James V of Scotland by proxy in Paris in May of 1538, and in person at St. Andrews on June 12th of that year. Their two sons, James and Arthur, died within weeks of one another in 1541. The king died in December of 1542, a week after the birth of their daughter and heir to the throne, Mary, Queen of Scots.
Mary of Guise replaced the ineffectual James Hamilton, Earl of Aran as regent in 1554, and arranged for the marriage of her daughter to the French dauphin. A Roman Catholic, she pursued pro-French policies, which embroiled her in civil war with the protestant Scottish nobles.
She was deposed on religious grounds in 1559. Suffering from dropsy, Mary died at Edinburgh Castle at the age of just 44. Her body was returned to France and given to her sister Renee, abbess of the Convent of the Abbaye Saint-Pierre-les-Dames which was completely destroyed during the French Revolution.