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CHARLIE DOES FUCKING PARKOUR???? that man is SCARY.
Didn't having a girlfriend, being a gamer, having glasses, being JACKED, having a brother, having a therapist, doing boxing classes WASN'T ENOUGH?
DUDE.
Like leave it some for me man like your only bad trait is that you're American what the fuck???
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i need to go.iii
I keep forgetting i havethings i NEED.to DO.
Abstract
The endocannabinoid system has been proposed to modulate a variety of physiological processes, including those that underlie cognition. The present study tested whether this system is tonically active in learning and memory by comparing CB(1) receptor knockout mice (CB(1)(-/-)) to wild-type mice (CB(1)(+/+)) in several Morris water maze tasks.
Also, the effects of three cannabinoid agonists, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), R-(+)-[2,3-dihydro-5-methyl-3[morpholinyl)methyl]-pyrrolo[1,2,3-de]-1, 4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate (WIN 55,212-2), and methanandamide, were evaluated in a working memory procedure.
Both genotypes exhibited identical acquisition rates in a fixed platform procedure; however, the CB(1)(-/-) mice demonstrated significant deficits in a reversal task in which the location of the hidden platform was moved to the opposite side of the tank.
This phenotype difference was most likely due to an increased perseverance of the CB(1)(-/-) mice in that they continued to return to the original platform location, despite being repeatedly shown the new platform location.
In addition, Delta(9)-THC (ED(50) = 1.3 mg/kg), WIN 55,212-2 (ED(50) = 0.35 mg/kg), and methanandamide (ED(50) = 3.2 mg/kg) disrupted the performance of CB(1)(+/+) mice in the working memory task at doses that did not elicit motivational or sensorimotor impairment as assessed in a cued version of the task.
Furthermore, doses of each drug that were maximally disruptive in CB(1)(+/+) mice were ineffective in either N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR 141716A)-treated CB(1)(+/+) or CB(1)(-/-) mice.
These results provide strong evidence that cannabinoids disrupt working memory through a CB(1) receptor mechanism of action, and suggest that the endocannabinoid system may have a role in facilitating extinction and/or forgetting processes.
"We survive by remembering but sometimes we survive by forgetting"
-Diana Salazar
im so dumb i thought i had work tonight cause i have work every sunday night and i coulda went somewhere with my friend and they're gone already so now i have to wait, when i coulda been with them the whole time -__- i showered, got ready and rushed to work and everything too.
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Sleeping is nice. You forget everything bad that happened. Just for a while.
I'll do anything I can just to forget.
I wanna forget you, forget anything and anyone having to do with you; I wanna forget this house, this town, these scumbags who I'm surrounded by; I wanna forget who I've lost, what I've lost, and what has been done that led to me losing them. The past few weeks, this week especially, I've been going out and getting fucked up almost every night. It's not even about having fun anymore. It's just about not wanting to think. My goal for almost every night is to get so fucked up that I can't even remember my own name anymore, let alone anyone else's. I thought I found someone to distract me from you, but I didn't. It was too good to be true, just like the others. Tell me why even after all this time, when we barely talk anymore besides the other night, I'm so stressed out over the fact that I'll be losing you in just a few short weeks? You were all I wanted, you've always been what I wanted; I was always just the idiot who was too scared to act on it, and now it's too late. You say that you'll always be here for me; but just give it a little time, you won't even remember my name anymore, when yours is and always will be burned into every piece of who I am.
