#ferroptosis

Turned out fine but if you ever needed any more confirmation that you're really good at what you do, this is it 👍 👍

Ferroptosis, a regulated cell death (RCD) process driven by iron-dependent lipid peroxidation, has emerged as a pivotal focus in recent therapeutic research for lung diseases. This comprehensive review synthesizes the latest breakthroughs in ferroptosis-based therapy development, highlighting the transformative potential of nanomedicine in the precise regulation of this cell death pathway-with…

An in vivo, noncanonical ferroptosis pathway, critical for tumor supression, is driven by reactive oxygen species-induced phosphatidic acid peroxidation at the ER under the control of the GPX1-OSBPL8 signaling axis. Read more about this post… Credits: Source Disclaimer

Hepatocellular carcinoma (HCC) is a major cause of cancer-related death and is often resistant to treatment, partly because it develops after decades of chronic injury in a metabolically heterogeneous organ. Anatomically, the liver is organized into lobules with three concentric zones, each with distinct gene expression and metabolic programs, but whether cancer favors any particular zone has…

For decades, we’ve understood cellular death through a few well-defined mechanisms, but what if there was another player on the stage, operating in the shadows? A groundbreaking discovery is rewriting our understanding of how cells expire, revealing a previously unknown form of regulated cell death with potentially massive implications for human health. Scientists have unearthed compelling…