Why Bill Gates thinks gene editing and AI could save the world
Microsoft co-founder Bill Gates has been attempting to improve the condition of worldwide wellbeing through his nonprofit foundation for 20 years, and today he told the nationâs premier scientific gathering that propels in artificial intelligence and gene editing could accelerate those enhancements exponentially in the years ahead.
"We have an open door with the advance of tools like artificial intelligence and gene-based editing technologies to fabricate this new age generation of health solutions so they are available to everybody on the planet. Furthermore, I'm very excited for this," Gates said in Seattle during a keynote address at the annual meeting of the American Association for the Advancement of Science.
Such tools promise to have a dramatic impact on several of the biggest challenges on the agenda for the Bill & Melinda Gates Foundation, created by the tech guru and his wife in 2000.
When it comes to fighting malaria and other mosquito-borne diseases, for example, CRISPR-Cas9 and other gene-editing tools are being used to change the insectsâ genome to ensure that they canât pass along the parasites that cause those diseases. The Gates Foundation is investing tens of millions of dollars in technologies to spread those genomic changes rapidly through mosquito populations.
Millions more are being spent to find new ways fighting sickle-cell disease and HIV in humans. Gates said techniques now in development could leapfrog beyond the current state of the art for immunological treatments, which require the costly extraction of cells for genetic engineering, followed by the re-infusion of those modified cells in hopes that theyâll take hold.
For sickle-cell disease, âthe vision is to have in-vivo gene editing techniques, that you just do a single injection using vectors that target and edit these blood-forming cells which are down in the bone marrow, with very high efficiency and very few off-target edits,â Gates said. A similar in-vivo therapy could provide a âfunctional cureâ for HIV patients, he said.
The rapid rise of artificial intelligence gives Gates further cause for hope. He noted that that the computational power available for AI applications has been doubling every three and a half months on average, dramatically improving on the two-year doubling rate for chip density thatâs described by Mooreâs Law.
One project is using AI to look for links between maternal nutrition and infant birth weight. Other projects focus on measuring the balance of different types of microbes in the human gut, using high-throughput gene sequencing. The gut microbiome is thought to play a role in health issues ranging from digestive problems to autoimmune diseases to neurological conditions.
âThis is an area that needed these sequencing tools and the high-scale data processing, including AI, to be able to find the patterns,â Gates said. âThereâs just too much going on there if you had to do it, say, with paper and pencil to understand the 100 trillion organisms and the large amount of genetic material there. This is a fantastic application for the latest AI technology.â
Similarly, âorgans on a chipâ could accelerate the pace of biomedical research without putting human experimental subjects at risk.
âIn simple terms, the technology allows in-vitro modeling of human organs in a way that mimics how they work in the human body,â Gates said. âThereâs some degree of simplification. Most of these systems are single-organ systems. They donât reproduce everything, but some of the key elements we do see there, including some of the disease states â for example, with the intestine, the liver, the kidney. It lets us understand drug kinetics and drug activity.â
The Gates Foundation has backed a number of organ-on-a-chip projects over the years, including one experiment thatâs using lymph-node organoids to evaluate the safety and efficacy of vaccines. At least one organ-on-a-chip venture based in the Seattle area, Nortis, has gone commercial thanks in part to Gatesâ support.
High-tech health research tends to come at a high cost, but Gates argues that these technologies will eventually drive down the cost of biomedical innovation.
He also argues that funding from governments and nonprofits will have to play a role in the worldâs poorer countries, where those who need advanced medical technologies âessentially have no voice in the marketplace.â
âIf the solution of the rich country doesnât scale down ⌠then thereâs this awful thing where it might never happen,â Gates said during a Q&A with Margaret Hamburg, who chairs the AAAS board of directors.
But if the acceleration of medical technologies does manage to happen around the world, Gates insists that could have repercussions on the worldâs other great challenges, including the growing inequality between rich and poor.
âDisease is not only a symptom of inequality,â he said, âbut itâs a huge cause.â
Other tidbits from Gatesâ talk:
When it comes to agriculture, climate change is making the challenges facing farmers in developing countries even more acute, Gates said. More extreme weather conditions could bring more floods, more droughts and more pests and plant diseases capable of wiping out crops. Gates pointed to efforts at CGIAR to develop more resilient strains of corn, rice and other crops, and at the University of Cambridge to build healthier soil. The Gates Foundation recently established a new initiative called Gates Ag One to support such innovations.
Gates said he was concerned about two trends in the distribution of health information. âOne is that titillating false information is more engaging than true information,â he said. The flap over the false linkage between vaccines and autism serves as an example of that, he said. âAnd then thereâs this general notion of, hey, if the experts say something, are they somehow biased or naive?â he noted. âThis is a fight. Will we go through a cycle where itâs not as acute as it is today? I donât know. Right at the moment, it doesnât feel that way.â
Gates said he subscribed to psychologist Steven Pinkerâs view that the world is getting better. âDespite that thereâs plenty to worry about ⌠we shouldnât lose sight of the fact that the progress has been absolutely phenomenal,â he said. âMany people are literally ahistorical to think that in a meaningful sense, 20 years ago or 40 years ago, life was better. Thatâs just not the case. Yes, there are huge problems, but if youâre a woman, if youâre gay, if you were subject to certain diseases, if you lived in developing countries, 40 years ago was dramatically worse than it is today.â




















