#detomidine

DETOMIDINE1H-Imidazole, 4-[(2,3-dimethylphenyl)methyl]-4-(2,3-Dimethylbenzyl)-1H-imidazole507876631-46-4[RN]7N8K34P2XH Molecular FormulaC12H14N2Average mass186.253 Da UNII-7N8K34P2XHдетомидинديتوميدين地托咪定 Formal Name5-[(2,3-dimethylphenyl)methyl]-1H-imidazole, monohydrochlorideCAS Number90038-01-0Synonyms DomosedanMPV 253AII Molecular FormulaC12H14N2 • HClFormula Weight222.7DetomidineCAS…

Datura innoxia indigenous shrub in South Asia region belongs to the family Solanaceae which contains medicinal important alkaloids (hyoscine, atropine, hycosamine, etc). Thirty adult rabbits of mixed breed, male and female were pretreated with 0.1 mg/500 mg of crude extract (1% of dimethyl sulfoxide (DMSO) solution) and injected 5 min later with 0.01 mg/500 mg of detomidine (group A, n=15) or Saline (group B, n=15). Mean arterial pressure, measurements and electrocardiography were performed for 65 min. After injecting crude extract of D. innoxia, the heart rate was increased by 45 and 46.34% in groups A and B, respectively. Heart rate remained increased after the injection of detomidine returning to base line values after 15 min. No increase in the mean arterial  pressure (MAP) was noted in group B rabbits. Crude extract shortened PR and QT interval in both groups but after detomidine, PR and QT interval were enlarged significantly at the end of the experiment. The second degree atrioventricular was blocked in two rabbits after 40 min only in group B. It was concluded that alkaloid present in D. innoxia prevented detomidine induced Bradycardia  and might be useful during combination against the Bradycardia induced by alpha-2 agonist in the rabbits. Author(s) Details

Dr. S. U. Rehman

Faculty of Sciences, University of Central Punjab, Lahore, Pakistan.

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