Like Wade has a kind-of-who-knows-at-this-point "Best" friend tech guy who kind of tolerates him and he tolerates that used to be Peter's college classmate. He almost took a gig from Osborn but actually was Bullseye fucking with him in revenge while dressed up in a Clint old suit. He got on a mission with Black Widow. He got beef with Avengers clones to a point the avengers themselves got to be involved. They don't like him he doesn't like them so they both agree to be civil to do the damn mission so everyone can go their own way. He's having a middle age crisis where he kind of wants to quit being a mercenary but he doesn't know yet who the fuck else he could be and all the reasons pointing up to be a hero are wrong and distorted in his own egoistic views.

A hit monkey want to fuckin kill him. The hit monkey doesn't know he's immortal. The hit-monkey never saw him personally but somehow set him up to get his jaw sucker punched by Spider-Man. Which results in the worst team ever for both of them. I sweat to god except from fucking Old man Logan, I've never seen Wade so stressed in working with someone. And while this whole shit storm works, Wade keeps bullshitting about Peter's life being so fucking easy and loved by the public and Peter has to stay there and listen to it. They bump into each other on the subway out of costume and Peter hates him on sight.

Wade doesn't want to be there and the first opportunity to bail on Spider-Man he takes it and Spider-Man on the other hand learns that Deadpool is immortal and kind of gets "Okay what if we let you get shot" and Wade is so offended he starts calling him names.

Wade goes to bother X-Men, X-men tells him to fuck off. Wade considers blowing up X-Men for full two panels. X-Men sends Domino who's kind of one of Wade's friend to fuck with Deadpool, we're convinced by two pages he beat the shit out of her, just to show up on the next pages that he actually made her fall over a bunch of pancakes.