So I liked Cornthian and everything involved with them back in the preboot, so I suppose my question if it isn't too spoilery is will we see any "fixed" amalgamates here / Reboot Cornthian (especially since we've seen Endogeny and they look the same)?
Asgore was already a well known scientist within monsterkind before they were sealed away along side Gaster. While his specialty is botany, he has more than enough experience in the medical field that people were comfortable bringing their ailing family to him sooner than in canon. With slightly more time on a group of dying patients, he discovered Determination and injected into them in a slightly different way than canon.
It's a safe assumption that Alphys injected the same amount into each group. However Asgore considered the will to live while administering the DT.
A group of mercenaries working on the edge of legality? Don't need too much more will to live, they are plenty willful as is.
A large group of the Royal Guard? Willful indeed but let's add a little more to even out any fluctuations.
A wife and mother with no battle experience? Oh, she needs a LOT of this.