#complex1

Complex 1 deficiency in a nutshell is basically a disease affecting the mitochondria, primarily caused by genetic defects and passed down to offsprings. The DNA that affects mitochondria, which is usuallt referred to as Mitochondrial DNA (or mtDNA for short) is located in the x chromosome of the sex chromosomes. This genetic defect causes a lack of complex 1 in the cristae of the mitochondria, since the whole chain of complexes is required to produce the maximum amount of ATP (energy for cells) that a mitochondria can produce, a lack of complex 1 heavily restricts the production of ATP, because complex 1 actually prevents the other complexes (complex 2, 3, and 4) from producing ATP efficiently. This ultimately means that the body is not receiving the energy it requires, this results in extreme fatigue and low muscle tone, it could become fatal, depending on what organ of the body is lacking complex 1, it mostly occurs in the brain, so in majority of the cases it has been terminal. Some symptoms include episodes of nauseousness and heavy breathing, low muscle tone, extreme fatigue, even depression. 

Above is a chart with data compiled by the 1000 Genomes Project, which is an international project to research and create the most detailed catalogue of human genetic variation. In the chart it is clear that the highest rate of mitochondrial disease exist within the South Asian race, predominantly in Souther Asian countries such as Pakistan, India, Nepal and even some countries in the middle east. The reason behind these countries having these diseases is purely luck, there are no lifestyle habits that lead to this disease, and even modern medicine does not have a cure, someone from that population got unlucky and had mutated genes, and passed them on to offsprings which in return created new generations of offsprings with the disease, ultimately spreading it. The second highest population with this disease are European countries such as Poland, United Kingdom, and Netherlands.

Project on the ability of collective housing to build town. A giant shared rooftop make link between different housing, just as the ground floor which is totally transparent space and offer a buffer zone between the road and the shared garden.