#casebasedreview

Abstract

Pyoderma Gangrenosum (PG) is a rare skin disorder that includes blisters, bullae, and ulcers, which can rapidly grow. Systemic Lupus Erythematosus (SLE) in association with PG is rarely reported, and the occurrence of PG earlier is relatively uncommon. A 33-year-old female patient known to have pyoderma gangrenosum presented with a 3-year history of polyarthralgia and morning stiffness involving both the hand and knee. She also complained of mouth ulcers, photophobia, fatigue, and sweating. Laboratory results disclosed anemia, leukopenia, and neutropenia. The autoimmune screen showed a positive ANA. Based on the clinical findings and positive immunologic studies, she was diagnosed with systemic lupus erythematosus. Initially, her general condition improved with an immunosuppressant, but the patient stopped her medication after three months of treatment. Although SLE is uncommon to develop after PG,

our case report shows that clinicians should consider it in any patient with a known history of PG who presents with obvious symptoms of an autoimmune disease.

Keywords: Systemic Lupus Erythematosus (SLE);