#aromasin

Aromasin Brings Hormonal Equilibrium by Controlling Estrogens 

EXEMESTANE (107868-30-4)

Exemestane,brand name Aromasin. It is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.It is a steroidal inhibitor of aromatase which effectively blocks estrogen synthesis in postmenopausal women and is used as therapy of estrogen receptor positive breast cancer, usually after resection and after failure of tamoxifen.

Status: In Mass Production

Unit: 25kg/Drum

Capacity: 1390kg/month

Exemestane (107868-30-4) video

Exemestane (107868-30-4) Description

Exemestane,brand name Aromasin. It is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.It is a steroidal inhibitor of aromatase which effectively blocks estrogen synthesis in postmenopausal women and is used as therapy of estrogen receptor positive breast cancer, usually after resection and after failure of tamoxifen. Exemestane has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury.

Breast cancer cell growth may be estrogen-dependent. Aromatase (exemestane) is the principal enzyme that converts androgens to estrogens both in pre- and postmenopausal women. While the main source of estrogen (primarily estradiol) is the ovary in premenopausal women, the principal source of circulating estrogens in postmenopausal women is from conversion of adrenal and ovarian androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) by the aromatase enzyme in peripheral tissues. Estrogen deprivation through aromatase inhibition is an effective and selective treatment for some postmenopausal patients with hormone-dependent breast cancer. Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as “suicide inhibition”. Exemestane significantly lowers circulating estrogen concentrations in postmenopausal women, but has no detectable effect on the adrenal biosynthesis of corticosteroids or aldosterone. This reduction in serum and tumor concentrations of estrogen delays tumor growth and disease progression. Exemestane has no effect on other enzymes involved in the steroidogenic pathway up to a concentration at least 600 times higher than that inhibiting the aromatase enzyme.

Exemestane (107868-30-4) Specifications

Product Name: Exemestane

Chemical Name: 6-Methyleneandrosta-1,4-diene-3,17-dione, Aromasin, Exemestano, Exemestanum

Brand Name: Aromasin

Drug Class: aromatase inhibitor

CAS Number: 107868-30-4

InChIKey: BFYIZQONLCFLEV-DAELLWKTSA-N

Molecular Formula: C20H24O2

Molecular Weight: 296.41 g/mol

Monoisotopic Mass: 296.178 g/mol

Melting Point: 155.13 °C

Freezing Point: No data available

Biological Half-Life: 24 hours

Color: White powder

Solubility: water solubility Non-soluble

Storage Temperature: -20°C

Gandhi Medicos We are Aromasin 25mg Tablets price Buy Online from India  Exporters & Bulk Suppliers from India,  If you become pregnant while taking AROMASIN, talk to your doctor immediately to learn about the potential risks to the baby. Taking AROMASIN during pregnancy or within 1 month of becoming pregnant can harm your unborn baby. Use effective birth control (contraceptive) during treatment with AROMASIN and for 1 month after your last dose of AROMASIN.

>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>