“I'll show you I'm not a child anymore.” 

Very often, we get stories in which the protagonist has a strong connection with his mother and a strained relationship with his father. The mother in this scenario is has no agency of her own - she is killed off very soon in the story, which traumatizes the protagonist and motivates him to take action. The father, in turn, remains an important, prominent figure, who influences the plot in various ways - even in absence.

With a Plague Tale: Innocence, we are dealing with a complete reversal of this pattern. Our protagonist has a strong emotional connection with her father, while her mother keeps her at a distance. The father, though a noble knight, is rather irrelevant to the plot, but the mother is continuously brought up as an alchemist whose research matters a great deal. When the Amicia de Rune voices her dissatisfaction with not getting enough attention, it is Lord de Rune who hears her out. In this family, it is the husband who makes excuses for the wife - not the other way round.