Sep 9, 2025
Cycle 1, Day 1 of the Alisertib clinical trial at Mayo! Let’s-a-go!
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Cycle 1, Day 1 of the Alisertib clinical trial at Mayo! Let’s-a-go!
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Come with me as I travel to Mayo for my clinical trial. It isn’t easy logistically or emotionally to keep leaving home and spending long days at the hospital waiting to meet doctors and waiting for scan results on MyChart. But I will keep doing it as long as there’s a chance that it keeps my cancer stable. According to a PubMed article about Alisertib (https://pubmed.ncbi.nlm.nih.gov/25728526/) 18% of participants with BC reacted positively and this was back in 2013. Surely the odds are higher now because they have had time to finetune the formulation.
The best case would be NED (No Evidence of Disease) or NEAD (No Evidence of Active Disease) but I will also take a stable, non-growing outcome. If the cancer maintains status quo and isn’t growing then it is considered a successful outcome. However if it shrinks in one area (say, the liver) and grows in another (the bones) then it is considered to be not working and they will take me off it and we move onto the next therapy.
We are also measuring the tumor markers (CA15-3) to make sure those are stable and measuring various blood work: absolute neutrophils to see how well my immune system is doing, and elevated ALT (alanine aminotransferase) numbers for my liver function. I am firmly in Cycle 2 (second month) of the clinical trial. At the start of Cycle 3 (third month, early Nov) I get "restaged" with follow-up CT/PET scans to finally ascertain whether the Alisertib is working and I keep going, or if it isn't. My brain is already frantically planning my next step, even though everybody tells you not to think too far ahead, you are not a statistic, medicine has come so far in x years, you are younger/healthier/more resilient than the average. My brain is embedded in so many different versions of the future I may as well be reading a "Choose Your Own Adventure" book from start to finish.
Stage 4 needs more. More funding, more research, more drugs. More lines of treatment before chemo or chemo-like drugs have to be used. More understanding of the emotional and psychological impacts of chronic illness. More safeguards against the toxicity of constant scans, radiation, nuclear medicines. More comprehensive data about genetic mutations in different racial groups (especially South Asians who get diagnosed at a later stage than other groups.)
This is why I don’t mind flying hundreds of miles to take part in this clinical trial. Alisertib has been in trial for various cancers for the past 10 years. Why isn’t it FDA approved yet? I am lucky that I am eligible for this and other trials. Generally, the earlier in your treatment you are, the more trials you have access to. I guess it is easier to track results on a younger healthier person with less co-morbidities. If Alisertib fails, I have other trials to fall back on. For now.
Me looking for anybody on my breast cancer forums, groups, boards, chats or chains taking Alisertib so I can trauma-bond (still haven’t found anyone!)