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for tomodachi life specifically, make sure you set a timezone in settings! you can have it match your pc's time for simplicity.

there are ostensibly keyboard controls, but they're a little wonky to figure out. if you can, plugging in any controller should work just fine. just make sure to select it in ryujinx's input settings! (you should also still be able to use your mouse for things like drawing facepaint!)

graphics settings will be on a per-pc basis, depending on your pc's strength. it's worth it to experiment with them and see what gives you the best performance. ryujinx will explain what each setting does if you hover over it!

the game crashed?

that's very likely to happen! on first time loading a scene, the emulator can sometimes struggle. it happened to me the first time i opened the mii editor, and the first time i opened the news station. you should be able to relaunch and everything will be fine. if it's happening super frequently, though, you may need to adjust your graphics or cpu settings!

a sixth thing i didn't think of?

feel free to leave a reblog with comment or send me an ask! if you need more specific guidance, i'll be happy to help! i'm not an expert on emulation, but if nothing else, i can try to point you towards a reddit thread that is more competent than i am