Medical Articles

DM oral med seem to be effective in symptoms of acute heart failure. Consider starting them before discharge

Alternative to antibiotics prophylaxis for UTI is effective

Participants with higher levels of the bacteriophage Caudovirales performed better on various tests of executive function and memory. Participants with higher levels of Microviridae performed worse on these tests. These findings were confirmed in another group of 942 people. When feces from humans with high levels of Caudovirales were transplanted to mice, the mice's performance on cognitive tests improved, and their brains were found to have up-regulation of genes known to be associated with superior cognitive abilities. Finally, specific Caudovirales phages were fed to fruit flies, and the performance of the flies on cognitive tests also improved.

Only alcohol use was shown to be a trigger of atrial fibrillation episodes during a 10-week, uniquely designed randomized trial. Not caffeine, exercise, sleep deprivation ( other common historically reported triggers)

For heavy alcohol drinkers, taking usual doses of tylenol (<6gm/ day x several days) can lead to acute liver injury.

Hemoglobin level is lower when the blood sample is taken in a patient who has been lying down.  

A small study where patients with melanoma resistant to immunotherapy when transplanted with stool from patients who had responded to immunotherapy later showed response to the therapy.

The use of Modified Geneva Score to risk stratify COPD exacerbation patients. A reminder to always think of PE when patients come in with COPD exacerbation my.

Gene editing restore vision in lab mice, raise hope of reversal of aging. First time such thing succeed in living animals instead of cells.

Approach to remove Pencilling allergy label. Low risk: urticaria to Pencillin more than 5 years ago, self limited rash, gi symptoms, remote child hood history, family history. Challenge with one oral dose of amoxicillin and observed 1 hour.

SGLT2 inhibitor, a diabetes pill, seem to be effective for heart failure with reduced EF, even for patients without diabetes. Improvement in hospitalization rates, death.

certain bacteria (Veillonella) is significantly overrepresented in elite athletes.  And this bacteria once transplanted from athletes stool to mice, it improve their atheletic performance

Using Capillary Refill Time to Guide Sepsis Resuscitation

What a person believe about their "genetic profile" altered their physiological response. Less physical endurance on treadmill after being told they have genes that predict for low capacity for exercise. Implications as to education, what we tell kids and to adults?

Endovascular thrombectomy 6-24 hours after onset showed significant improvement for patients with small volume infarct on imaging (ICA, proximal MCA).

Dual antiplatlet therapy after high risk TIA or minor stroke had better outcomes than single antiplatlet. Effect mostly in the first week.

Salt restrictions in CHF, not much evidence.