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Agios Pharmaceuticals, Inc. (Nasdaq: AGIO) 19.6% LOWER; announced that it is no longer developing its second pyruvate kinase-R (PKR) kmspico download free , AG-519, and withdrew its investigational new drug (IND) application yesterday following a verbal notification of a clinical hold from the U.S. Food and Drug Administration (FDA). These decisions do not affect the Companys ongoing global Phase 2 study (DRIVE PK) for AG-348, a novel, first-in-class activator of both wild-type (normal) and mutated PKR enzymes. Agios is advancing AG-348 into pivotal development as the first potential disease-modifying treatment for pyruvate kinase (PK) deficiency.

Vericel Corporation (NASDAQ: VCEL) 15.7% LOWER; announced the pricing of its previously announced underwritten public offering of 6,200,000 shares of its common stock, offered at a price to the public of $2.75 per share

Jabil Circuit (NYSE: JBL) 10.6% HIGHER; reported Q1 EPS of $0.69, $0.05 better than the analyst estimate of $0.64. Revenue for the quarter came in at $5.1 billion versus the consensus estimate of $4.91 billion. GUIDANCE: Jabil Circuit sees Q2 2017 EPS of $0.35-$0.57, versus the consensus of $0.46. Jabil Circuit sees Q2 2017 revenue of $4.2-4.5 billion, versus the consensus of $4.36 billion.

Horizon Pharma (NASDAQ: HZNP) 9% HIGHER; entered into a rebate agreement with Express Scripts (NASDAQ: ESRX), which secures formulary status for DUEXIS, VIMOVO, PENNSAID 2% w/w and RAYOS® Delayed-Release Tablets. Mizuho Securities upgraded Horizon from Neutral to Buy.

TherapeuticsMD (NYSE: TXMD) 7.6% HIGHER; Cantor Fitzgerald initiated coverage with an Overweight rating and a price target of $34.00

Finisar Corporation (NASDAQ: FNSR) 5% LOWER; announced the pricing of its previously announced offering of $500,000,000 aggregate principal amount of its 0.50% Convertible Senior Notes due 2036 in a private placement.

Pioneer Energy Services Corp (NYSE: PES) 5% HIGHER; Goldman Sachs upgraded from Neutral to Buy with a price target of $7.50.

Nordstrom (NYSE: JWN) 3.6% LOWER; JPMorgan downgraded from Neutral to Underweight with a price target of $48.00 (from $55.00).

Trina Solar Limited (NYSE: TSL) 3.5% HIGHER; announced that the Company's shareholders voted in favor of, among others, the proposal to authorize and approve (i) the previously announced agreement and plan of merger dated August 1, 2016 by and among Fortune Solar Holdings Limited, Red Viburnum Company Limited and the Company, pursuant to which Merger Sub will be merged with and into the Company with the Company continuing as the surviving company as a wholly-owned subsidiary of Parent after the merger, (ii) the plan of merger required to be filed with the Registrar of Companies of the Cayman Islands, substantially in the form attached to the Merger Agreement, and (iii) any and all transactions contemplated by the Merger Agreement, including the Merger.

Oracle (NYSE: ORCL) 2.2% LOWER; sees Q3 adjusted EPS in constant currency of $0.61-$0.64 vs the consensus of $0.64. Revenue is seen up 3%-5% in constant currency.

Gilead Sciences (Nasdaq: GILD) 1.8% LOWER; must pay Merck (NYSE: MRK) $2.54 billion for using a patented invention as the basis for its blockbuster drugs Sovaldi and Harvoni to treat Hepatitis C, according to Bloomberg, citing a federal jury in Delaware.

Las Vegas Sands (NYSE: LVS) 1.5% HIGHER; Goldman Sachs initiated coverage with a Buy rating and added the stock to its Conviction Buy List with a price target of $68.

Merck (NYSE: MRK) 1.2% HIGHER; Gilead Sciences (Nasdaq: GILD) must pay Merck (NYSE: MRK) $2.54 billion for using a patented invention as the basis for its blockbuster drugs Sovaldi and Harvoni to treat Hepatitis C, according to Bloomberg, citing a federal jury in Delaware.

Malwarebytes Anti-Ransomware to bezpłatne narzędzie, która wykorzystuje zaawansowaną technologię w celu ochrony komputera przed przestępczym oprogramowaniem typu ransomware (np. CryptoLocker, CryptoWall czy CTBLocker).

Galeria programu image image image Zasada działania Malwarebytes Anti-Ransomware jest wyjątkowo nieskomplikowana, ale za to bardzo efektywna. Narzędzie monitoruje wszystkie procesy zachodzące w systemie operacyjnym Windows i zawartość dysku twardego w czasie rzeczywistym po to, by wykryć i zablokować ransomware, a następnie przenieść je do kwarantanny. W ten sposób program oferuje pełną ochronę komputera, a jednocześnie pozwala użytkownikowi na kontrolowanie podejrzanej zawartości.

Dlcracked.com Ransomware jest szczególnie niebezpieczne, bowiem po zainfekowaniu komputera oprogramowanie szyfruje dane użytkownika, które mogą zostać odblokowane zazwyczaj po uiszczeniu stosownej opłaty. Szczegółowe informacje na ten temat zostają opublikowane w specjalnej notatce, która pojawia się na komputerze po aktywowaniu przestępczego oprogramowania.

Malwarebytes Anti-Ransomware nie obciąża zasobów komputera i bezproblemowo współpracuje z głównym programem antywirusowym, stanowiąc jego uzupełnienie.

Gathering customer data is about knowing more about your customers, so you can build an emotional connection with them and encourage them to be loyal to your brand. Today, consumers have come to expect a more personalised customer experience from every brand they interact with in their daily lives. However, in order to get them to provide their data, the consumer wants a reason to do it and will generally want something in exchange. In this sense digital music acts as an incentive for the consumer to drip-feed their personal data, in return for free music.

The data challenge

Brands need to glean vast amounts of qualitative data about their customers, without making them feel uncomfortable or suspicious, in order to differentiate their approach.

Thus, two guys with the same demographic profile – similar age, with two kids, comparable earnings, living on the same street – are targeted by some brands as being exactly the same. However, they are likely to have very different interests, tastes, beliefs, commutes and preferences.

The more astute brands have been able to link customers’ data garnered from their social media accounts, their mobile devices and the apps they use. As well as the basic demographics social media gives them, these brands are also able to uncover much richer data, like their customers’ weekly activities, footprint, behaviours, preferences and moods to find out what really makes them tick and how to build an emotional connection with them.

Using music as a ‘honeypot’

Everybody loves music and brands that are using streaming music services to engage customers have been able to build an intimate and mutually valuable relationship with them by providing the music. In return, digital music acts as a ‘honeypot’ to glean the insights needed to profile specifically each customer.

Music can be the enabler that gives customers a reason to connect with your brand and to download your app. It will be then be up to brands to adopt a true customer-driven approach to their global loyalty strategies based on the intelligence collected.

However, brands need to be careful how they build up detailed profiles on consumers, many of whom are worried about their privacy already. Brands can be put in an awkward position if they spook their users by appearing to know too much.

As a general rule, the more permissions an app requests, the less likely it is that people will use social media accounts to log in. Brands should start with the public profile information and afterwards use creative approaches to ask for additional personal information over time. The brand could, for example, offer a user with a birthday that day tickets for the concert of their favourite band in the closest city from home. They would therefore need to provide their date of birth and postcode in order to enter such a competition.

Their personal profile becomes more detailed over time, giving the brand a much better understanding of its customer and their interests and preferences.

The benefit of the mobile first music experience

Nowadays, music is a mobile first experience and compared to other devices, smartphones can garner new valuable user’s data via their apps, social media and location-based services. We could discover that a customer spends most of their time in the city, and until that time we had targeting them with offers mostly in their home suburb.

By offering free music in their app, McDonalds can provide a reason for its loyal customers to connect with the brand on a daily basis. In return, the fast-food brand would know more about its customers, their social media interactions and location. They may discover that few customers interacted with KFC content recently and that they engaged specifically with entertainment and sport content. Therefore they could refine their tactics and provide a more personalised brand experience and specific location-based offer.

Streaming music has wrongly been viewed as a broadcast channel only, but is actually a highly targeted narrowcast channel that provides brands the opportunity to offer a very niche group a specifically personalised offering based on their tastes, passions, moods and location in exchange for a great music experience.

Leveraging personalisation with music tastes

Here again music can help. People tend to not listen to a set music genre anymore but their consumption habits are more mood, time and activity related. Those brands that offer digital music can gauge their customer’s current mood or activity and are able to take the personalisation approach one step further.

It’s very valuable for a number of relevant brands to be able to package up a personalised offering to all the fans of a particular artist or the businessmen who go for a workout before or after work. Virgin Airlines could offer special discounts to Katy Perry’s fans to fly to her next concert and Nike could promote their latest running shoe technology on a workout themed station after the average workday finishes. Knowing how your customers tick and what they are into at the moment makes all the difference.

Why are music and data well matched?

Providing a personalised customer experience based on intelligence rather than guesswork is now essential for all brands to ensure customer loyalty. Digital music can be used as an window 7 activator to collect the right personal data required to profile them appropriately.

Designing great user experiences that are relevant for each specific persona is the key challenge. Brands that base these offerings on current data gleaned about their customers’ interests, beliefs, moods, activities and locations are winning the battle. Music is a potent option to gather this important data, while building long-term relationships with your customers.

Con Raso is managing director of Tuned Global Pty Ltd. Con has had over 20 years’ experience in physical and digital distribution of music. Over the past 10 years this experience has focused on internet based distribution particularly within the business-to-consumer entertainment market, including developing applications and systems to enable enterprises to utilise music as a potent marketing tool.

MONTREAL, QC / January 18, 2016 / Earth Alive Clean Technologies Inc. (CSE: EAC) ("Earth Alive" or the "Company") is pleased to report significant increases in banana crop yields by a factor of 100% to 200%, over the regional average, for producers using Soil universal keygen generator 2016 (TM).

On May 13, 2015, Earth Alive announced it had shipped over $200,000 of organic crop inputs, including the Company's biofertilizer technology, Soil Activator(TM), to the Asociacíon Bananos Ecológicos de la Línea Noroeste (BANELINO). BANELINO, a large-scale certified organic and fair trade banana co-operative located in the Dominican Republic, began the application of the Company's input products on approximately 300 hectares of their members' organic banana plantations. By October of 2015, producers were already reporting enhanced banana growth, and the final impact of Earth Alive's biofertilizer on plantations has resulted in harvests that have significantly outperformed average yields in the region.

"Earth Alive's products have really made a significant difference in our yield results," stated Gustavo Gandini, BANELINO's Technical Director. "Our region was hit with drought this year, and banana yields have suffered because of this. In plantations where we applied the Earth Alive products, we are harvesting double, and in some areas even triple, the regional average," he concluded.

At the heart of Earth Alive's product line is Soil Activiator(TM), an organic-compliant bio fertilizer for sustainable agriculture, containing a proprietary blend of naturally occurring, beneficial microbes and an all-natural synergistic active. Soil Activator(TM) is designed to increase the availability of nutrients in the soil, which are often trapped and "hidden" from crops; it can be used alone in organic production, or in combination with synthetic inputs to obtain higher yields in conventional production. In addition to Soil Activator(TM), BANELINO growers also applied other inputs from Earth Alive's Big Blue product line, including WAVE sea minerals and ALGA liquid seaweed.

"Earth Alive's innovative input products maximize the efficient use of available fertilizer resources in sustainable agriculture," said Simon Neufeld, Chief Agronomist at Earth Alive. "Using Soil Activator(TM) and Big Blue in our custom-designed fertilizer program is helping BANELINO's organic banana producers achieve, and exceed, conventional yields and financial revenues in their region."

Miguel Monroy, Earth Alive’s Director of Business Affairs, stated, “Bananas are a major food crop in Latin America, with over one million hectares planted in various countries. “The fertilizer market for these banana crops alone is in excess of $100 million annually, representing a substantial market opportunity for Earth Alive's product line.” He further added, “Soil Activator(TM) is a non-crop specific fertilizer, and organic production of all types of crops is one of the fastest growing sectors in the global food industry”.

Michael Warren, Earth Alive’s Vice President of its Ag Division, concluded by saying “To help growers meet this rapidly increasing demand, we are currently identifying, and in discussion with, potential distributors in the southern hemisphere to expand our distribution into the Latin American banana industry, as well as in various other crop industries.”

About BANELINO:

Banelino is a Fair Trade banana cooperative located in the Northeastern region of the Dominican Republic. With approximately 300 small-scale producer members, the coop ships roughly 30,000 boxes of bananas weekly. Fertilization with Earth Alive’s Soil Activator(TM) product was carried out in the second half of 2015 on approximately 300 hectares of their members’ organic banana plantations.

For more additional information, please visit: [email protected]

About EARTH ALIVE CLEAN TECHNOLOGIES:

Earth Alive aims to be a key player in world markets of environmentally sustainable industrial solutions. The company works with the latest innovations in microbial technology to formulate and patent innovative products that can tackle the most difficult industrial challenges, once only reserved to environmentally harmful chemicals and additives. The company is focused on environmental sustainability in 1) dust control for the mining industry, and 2) the agriculture industry.

For additional company information, please visit: www.earthalivect.com

The CSE has neither approved nor disapproved the contents of this press release. The CSE does not accept responsibility for the adequacy or accuracy of this release.

Forward Looking Information

Except for statements of historical fact, this news release contains certain forward-looking statements within the meaning of applicable securities law. Forward-looking statements are frequently characterized by words such as “plan”, “expect”, “project”, “intend”, “believe”, “anticipate”, “estimate” and other similar words, or statements that certain events or conditions “may” occur. Although Earth Alive believes that the expectations reflected in the forward-looking statements are reasonable, there can be no assurance that such expectations will prove to be correct. Such forward-looking statements are subject to risks and uncertainties that may cause actual results, performance or developments to differ materially from those contained in the statements. Except as required under applicable securities legislation, the Company undertakes no obligation to publicly update or revise forward-looking information, whether as a result of new information, future events or otherwise.

Earth Alive Clean Technologies Inc., 1001, Lenoir Street, Suite B-338, Montreal (Qc) Canada H4C 2Z6 T.(438) 333-1680

For media information and interview requests, please contact: Mr. David Gilmour (e) [email protected] (p) 514-814-2899

For investor relations, please contact: Mr. Frédérick Chabot (e) [email protected] (p) 438-863-7071

DISCLOSURE: The views and opinions expressed in this article are those of the authors, and do not represent the views of equities.com. Readers should not consider statements made by the author as formal recommendations and should consult their financial advisor before making any investment decisions. To read our full disclosure, please go to:

One of the most challenging aspects of Windows 10 leading up to and following its launch in late July of this year was that Windows 7/8 product keys could not be used to directly activate the freshly installed operating system.

This meant users had to initially upgrade their Dlcracked.comfree system and then verify it was upgraded before performing a clean install using upgrade media and ISOs. This process insured the hardware had a digital entitlement and from that point a fresh install was possible on that same hardware.

Last week, with the release of the November Update for Windows 10, users no longer have to go through that initial upgrade process and obtaining that digital entitlement  to perform a clean install on a Windows 7 or 8.1 system.

All users have to do now is initiate the clean install using the Media Creation Tool from Microsoft and Windows 10 will now accept a Windows 7/8 product key to activate the system in this latest release.

The product key can be entered during the installation process or afterwards through the Settings app. This gallery will walk you through those steps for activating Windows 10 with your Windows 7 or 8 key in the Settings app.

That is one of the tips Dr. Mehmet Oz told a sold-out group Wednesday at a pledge drive for the Children's Hospital at Erlanger. Oz, a star of daytime TV, radio anchor person, creator, speaker and rehearsing heart specialist, made an extraordinary excursion to the Embassy Suites in East Brainerd for the occasion, volunteering his time for the $40 million doctor's facility, which is set to kick things off in 2017.

Dalton occupant Judy Kotch, a resigned school transport screen who watches over her three grandchildren, said she welcomed Oz's appearance and his message.

"I adore Dr. Oz," she said. "I watch his demonstrate constantly, and I loved his message to the group of onlookers about getting enough rest and eating great."

Oz, who has degrees from Harvard, University of Pennsylvania School of Medicine and the Wharton School, said an absence of value rest is "a standout amongst the most undervalued issues confronting individuals today."

It's turned into an issue for not just the general population he gets notification from in his ventures, he said, however in his own life, too.

"I utilize a rest measuring apparatus that I keep by my bedside that lets me know how I dozed," he said preceding his presentation. "I can generally tell on the off chance that I didn't rest soundly, yet I can't explain why. Perhaps the canine came in or my legs were moving. On the off chance that my significant other and I had a battle, I don't rest soundly. This gives me a chance to monitor what was going on."

The rest measuring instrument is like runners or bikers keeping a coach log or individuals on weight control plans keeping a calorie counter, he said, and gives them a chance to report and distinguish designs.

"Simply measuring the movement and staying alert can be useful," he said.

Oz consented to be the included visitor at the pledge drive two weeks back in light of his association with Erlanger President Kevin Spiegel, whom he has known for quite a long while. Oz likewise said he gets a kick out of the chance to travel both out of his own longing to encounter new things and spots furthermore to chat with individuals to find what is on their brains.

"I gained a great deal just from the inquiries I got today about what individuals are agonized over," he said. "In the event that I simply sit in my office at 30 Rock [30 Rockefeller Plaza] in New York City, I'm doing a damage."

What individuals are letting him know is that "terrorism is the No. 1 thing on individuals' brains at this moment," he said. "Indeed, even here. That astounded me. No. 2 is the race."

The main three social insurance issues confronting Americans, as indicated by his examination and perceptions, include weight control and the enthusiastic anxiety that accompanies it, absence of value rest and ceaseless agony.

"Also, agony can impact poor rest," Oz said.

Individuals have such a great amount of access to restorative data by means of cell phones and TV programs like his own, he said, yet what they need is for somebody to demonstrate to them the best approach to feel better.

"We do have an excess of data, however some of it is basic," he said. "What individuals need is a field guide. Demonstrate to me the way. They know it can be slippery, yet regularly they are willing in the event that it improves them feel, yet what they need is individuals like me to demonstrate to them the way. Our test is to locate the best answer for every person."

Kids' Hospital CEO Don Mueller told the gathering of people that "Chattanooga merits a world-class kids' doctor's facility" and, when finished, the new office will be the most essential building worked in Chattanooga.

"The two things individuals need to know when they are taking a gander at moving are 'The place will my children be going to class?' and 'Who will deal with them' ought to something happen?" Mueller said.

Madurai, June 13: Ramadan quotes, the holy month of Islamic lunar calendar, has begun. Muslims across the world observe fast and perform special prayers during the month of Ramadan, also known as Ramazan. During the month of Ramadan, Muslims observe fast from dawn to dusk. In a nice gesture, a hospital in Madurai serves special meal to Muslim patients and their relatives at 3 AM for sehri. Sehri or Suhur is an Islamic term referring to the meal consumed early in the morning by Muslims before fasting.

However fasting is not mandatory for the sick person during Ramadan, but their relatives who stay in hospital to look after them faces problem in observing fast. In order to help those patients and their attendants, staff of Meenakshi Mission Hospital and Research Centre in Madurai offers special meal for them so that they can get food for sehri. The food is also served to them at the time of iftar. (ALSO READ: Ramadan 2016: Tips to stay healthy during Ramzan fasting)

“We give them dates, which help to balance the acidity in their stomach after the long fast, and then the meals, which would include one non-vegetarian dish, fruits and juice,” Vivekanandhan, senior manager of catering at the MMHRC, told Times of India. The decision of serving food was taken after the hospital authority realised that access of food was difficult for Muslims during the early morning hours.

“I am able to fulfill my needs like I do at home and the food is also good,” Abdul Riyaz, who has come from Ramanathapuram and is staying with his wife, was quoted as saying. At the time of iftar, the hospital staff offers ‘nombu kanji’ (fasting gruel) that includes rice, dhal and mincemeat. Non-Muslims are also allowed to take benefit from the initiative. After knowing about the facility, many outsiders also come to the hospital restaurant for the early morning meal, for which they are charged Rs 150.

According to a certain blockbuster video game series, with a fourth installmentnow hitting store shelves, war never changes. But the Internet, smartphones, and all of the other wonderful/terrible new technology we have at our disposal have totally changed the nature of conflict, and not just geopolitical ones. The methods a rogue state might use to launch digital attacks on other countries are the same methods malware creators use to profit from victims. All this to say that the latest malicious app we've heard about from Malwarebytes has a method, targeted region, and even name straight out of a Cyber Cold War.

Agent X Malwarebytes identifies the Trojan as the appropriately menacing Android/Trojan.SMS.Agent.apa. But like any good enemy agent, it goes by the much more unassuming Installation (Ustanovka.apk) on the Russian third-party app stores it haunts. So once again, Russian speakers should be especially vigilant for spies.

Once SMS.Agent infiltrates your phone, it begins an operation that would make the most grizzled old spymaster proud. The malware captures SMS messages, steals contact information, and is capable of downloading additional, potentially malicious apps. That's a lot of sensitive data being looked at by prying eyes without the victim even knowing.

Apps that steal text messages are nothing new. Sometimes they're even installed by paranoid lovers rather than cold-hearted hackers. But when dealing with malware you should prepare for the worst, which in this case means assuming your private information is being stolen by criminals.

There's one piece of good news. Malwarebytes says SMS.Agent doesn't attempt to root its host device. That means any additional installs would have to be approved by the user, who would hopefully be discerning enough to avoid downloading even more malware. Also, malware without root access is much easier to remove. But SMS.Agent could very well use tricky, misleading language to keep itself active and installed while trying to convince the user to say yes to more downloads.

Staying Safe The best way to avoid any malware that thrives on third-party markets is to only download Android apps from official channels like the Google Play store. For an essential layer of extra protection you should also acquire some analyst-approved Android antivirus software. Stay away from free sms to pakistan from uae. Agent and hold onto your own Android agency.

A MARRIED man with a "deep and unhealthy" interest in young girls is behind bars after being caught with hundreds of pictures of child abuse.

Michael Patterson chatted with other paedophiles online about having sex with children and shared some of his sickening catalogue of photographs.

The 53-year-old also pretended to be a child so he could communicate with girls in internet chat rooms, prosecutor Paul Reid told Teesside Crown Court.

Patterson, of Middlesbrough, was jailed for 20 months after Judge Simon Bourne-Arton, QC, condemned his interest.

He said: "These are not victimless crimes . . . the girls who are the subject of sex in the photos actually had to undergo what you are looking at.

"The more people like you, the more that there will be a market for them, and young girls will have to be the subject of these depraved acts."

Patterson admitted two charges of making indecent images of children - more than 1,000 in total - and one count of distributing indecent images.

His lawyer, Robert Mochrie, admitted a report written by a probation officer was "disturbing reading" but said Patterson had been brutally honest.

Mr Mochrie added: "Perhaps this candidness is the first step on the ladder towards rehabilitation . . . he has not tried to cover up his actions."

Mr Reid said police raided Patterson's home and seized a computer and a laptop after they became aware he was streaming pictures and videos online.

The majority of the images were of girls aged between two and ten, said Mr Reid, and Patterson confessed to having a particular interest in 12- and 13-year-olds.