IJBIO

ABSTRACT:

In the last years of the previous century, I encountered some books that reported proves that energy intake was (positively) associated with malignancy over vascular risks. Prevention was obtained by a mean 30% energy intake decrease. The book of reference 1 was repeatedly printed and published, but it is not alone.

Up to recent days, a 30% lifelong decrease of energy intake seemed as prohibitive in humans. This may be the explanation of the poor spread of the information on the association between cancer and energy intake. We have published that meals promoted by Initial Hunger (IH) may be “easily” trained and eliminate insulin resistance. This is accomplished by a loss of about 30% energy intake. Part of population does even not require the suggestion for a change in intake. After training, about a third of investigated adults or toddlers maintained the energy intake, Blood Glucose (BG), Resting Metabolic Rate (RMR) and insulin sensitivity that they had at recruitment. The implementation of a meal pattern where meals are induced by IH is quite easy (IH meal pattern or IHMP) in past experience. Part of population adopts and maintains this meal pattern by free choice. Objectively, the adoption of Initial Hunger Meal Pattern (IHMP) creates a different life. Table 1 reports effects on energy metabolism, Table 2 reports effects on insulin sensitivity and Body Mass Index (BMI). At recruitment, the investigated population presents individuals that have mixed levels of energy availability

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ABSTRACT:

Many people worldwide do not have adequate and regular access to even a limited basket of basic, low-cost essential medicines. The high burden of out-of-pocket payments for medicines and health products frequently increase inequities in many countries, leading to catastrophic payments and impoverishment of individuals and families. Poor selection of medicines and health products, inadequate domestic or government financing and ineffective policy interventions and processes to manage expenditure and out of pocket expenditure (for medicines and some vaccines) contribute to a lack of access to medicines and health products and unaffordable prices. WHO in its Development of the roadmap on access to medicines and vaccines 2019-2023 has emphasized that- It is difficult to achieve efficiency in the hospital pharmaceutical system if there are too many medicines. All aspects of drug management, including procurement, storage, distribution and use, are easier if fewer essential medicines must be dealt with (WHO Bulletin).

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