Bangin’ Fog Machine

Fellow tweakers,

A couple of weeks ago a paper was published titled The Main Molecular Mechanisms Underlying Methamphetamine- Induced Neurotoxicity and Implications for Pharmacological Treatment. I highly recommend reading it. 

Here are the quick list of substances which may reduce the harm of meth use according to the paper. Note that you may not be able to find all of these in your local pharmacy.

1. Fighting neurotoxicity 

Vitamin C, selenium supplementation for at least 13 weeks, lithium,  valproate and nicotinamide (a form of vitamin B3) all have been shown to reduce meth’s neurotoxicity (brain cells death).

2. Fighting excitotoxicity¹

Melatonin, N-acetylcysteine and dizocilpine have been shown to reduce the damage due to overstimulation of your neurons.

3. Fighting neuroinflammation

Minocycline and ibudilast have shown potential to treat neuroinflammation due to meth abuse.

4. Fighting long-term effects

9 cis-retinoic acid (derivative of Vitamin A),  7, 8-Dihydroxyflavone are undergoing clinical trials with promising results.

That’s all! Stay safe. Tweak smart!

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The truly burning sex question of our time, answered with help from a doctor who is somehow not offended by it

By Stacey Grenrock Woods

Aug 7, 2009

Sex is better on crystal meth because both influence dopamine, a neurotransmitter in the brain that activates a certain pleasure center — the one that also makes you want to cover your windows with aluminum foil. "What happens with crystal and the dopamine is that one particular aspect of sex gets very exaggerated, which is the aggressive, sort of animalistic kind of sex," says Dr. Steven Lee, psychiatrist and author of Overcoming Crystal Meth Addiction.

However, I'm just getting a report from the wires that meth has some negative effects. "Dopamine is the aggressive brain chemical and serotonin is the intimacy chemical," says Dr. Lee, "so all of that sensual experience really gets drowned out with the crystal."

Too much methamphetamine will damage this dopamine system, thereby decimating your ability to feel pleasure about anything. To remedy this, you will need handfuls of pure Ecstasy. Otherwise, you'll be stuck in what's called "anhedonia," which addicts describe as "kind of a flat, gray haze that people live in."

Whatever. It can't be much worse than Riverside.