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In the pharmaceutical industry, the demand for high-quality intermediates continues to rise, especially for complex drug molecules such as Ruxolitinib, a well-known JAK1/JAK2 inhibitor. One of the essential chemical components behind its production is 1-(1-ethoxyethyl)-4-iodo-1H-pyrazole (CAS No. 575452-22-1). This compound plays a vital role in the multi-stage synthetic pathway that leads to the formation of Ruxolitinib. VidgasTech is committed to supplying this intermediate with exceptional precision, purity, and reliability for pharmaceutical research and manufacturing.

Understanding the Importance of Ruxolitinib Intermediates

Ruxolitinib has become a widely used therapeutic solution in the management of myelofibrosis, polycythemia vera, and other conditions involving overactive JAK signaling pathways. The success of its formulation depends significantly on the quality of its core intermediates. Among these, 1-(1-ethoxyethyl)-4-iodo-1H-pyrazole stands out due to its structural relevance in building the pyrazole ring that forms the backbone of the final active pharmaceutical ingredient (API).

What is 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole (CAS 575452-22-1)?

This compound is a highly specialized pharmaceutical intermediate used in advanced organic synthesis. It exhibits excellent chemical stability and is used extensively in the preparation of complex heterocyclic molecules.

Key Features:

Molecular component supporting Ruxolitinib formation

High purity essential for efficient downstream reactions

Stable and consistent performance in multi-step synthesis

Suitable for both research and industrial-scale production

Its importance lies not only in its role as an intermediate but also in how its purity directly influences the final API yield and quality.

Role in the Synthesis of Ruxolitinib

During Ruxolitinib production, 1-(1-ethoxyethyl)-4-iodo-1H-pyrazole acts as an essential building block for the formation of the core heterocyclic structure. Pharmaceutical manufacturers rely on this intermediate to ensure:

✔ Improved reaction efficiency

✔ Reduced impurities

✔ Better reproducibility across batches

✔ Compliance with global regulatory standards

By integrating high-purity intermediates like this one, manufacturers can achieve smoother synthesis pathways and more reliable API outcomes.

VidgasTech: A Trusted Supplier of Ruxolitinib Intermediates

VidgasTech is a leading provider of pharmaceutical intermediates, offering precision-manufactured compounds tailored for research and industrial use. With a strong focus on quality, consistency, and customer satisfaction, VidgasTech ensures that every batch of CAS 575452-22-1 meets stringent quality parameters.

Why Pharmaceutical Manufacturers Choose VidgasTech:

✔ High purity & analytical validation

✔ Global supply capability

✔ Secure packaging and safe logistics

✔ Technical support for scalable synthesis

✔ Compliance with industry standards

The company’s strong commitment to delivering innovative and dependable chemical solutions has made it a preferred partner for API manufacturers worldwide.

Applications Beyond Ruxolitinib

While its main application lies in forming Ruxolitinib, 1-(1-ethoxyethyl)-4-iodo-1H-pyrazole is also useful in:

Advanced organic chemistry research

Heterocyclic compound development

Custom synthesis projects

Drug discovery and molecular modification

Its versatility makes it valuable for multiple chemical and pharmaceutical developments.

Conclusion

1-(1-ethoxyethyl)-4-iodo-1H-pyrazole (CAS 575452-22-1) is a cornerstone intermediate in the synthesis of Ruxolitinib and other complex heterocyclic molecules. Ensuring the quality and purity of this intermediate is essential for achieving optimal pharmaceutical manufacturing outcomes. VidgasTech continues to lead the way by providing reliable, high-standard intermediates that support the global pharmaceutical industry.

The pharmaceutical industry relies heavily on high-quality intermediates to develop advanced therapeutic molecules. One such important intermediate is 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole (CAS No. 575452-22-1), widely recognized for its role in the production of Ruxolitinib, a well-known JAK inhibitor. VidgasTech is a trusted supplier providing reliable pharmaceutical intermediates to support research, formulation, and large-scale manufacturing.

What Is 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole?

This compound is a specialized pharmaceutical intermediate known for its stability and compatibility in multi-step drug development processes. Key identifiers:

Chemical Name: 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole

CAS Number: 575452-22-1

Category: Ruxolitinib Intermediate

Industry Use: Pharmaceutical research & manufacturing

Its structural relevance is essential in facilitating efficient API development, making it an important material for Ruxolitinib production.

Role in Ruxolitinib Intermediates

Ruxolitinib is an important therapeutic agent used for managing conditions such as:

Myelofibrosis

Polycythemia vera

Certain immune-related disorders

To ensure efficient synthesis and high-purity final API, intermediates like 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole are used at specific stages in the production pathway. Their performance and quality directly impact the consistency of downstream processes.

Why VidgasTech Is a Preferred Partner

VidgasTech has established itself as a reliable supplier of pharmaceutical intermediates, backed by years of industry experience. Customers worldwide trust VidgasTech for:

✔ High-purity intermediates suitable for research and commercial applications

✔ Consistent quality control for each batch

✔ Reliable global supply and timely delivery

✔ Competitive pricing for bulk and custom requirements

✔ Responsive customer support and documentation assistance

Our focus on quality and customer satisfaction ensures long-term partnerships with manufacturers and research organizations.

Quality Assurance & Standards

VidgasTech ensures that all intermediates, including 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole, meet strict quality benchmarks:

Analytical testing & purity verification

Industry-standard documentation

Safe packaging for domestic & international shipments

Batch consistency and compliance

This makes VidgasTech a dependable source for pharmaceutical intermediate needs.

Applications Across the Pharmaceutical Sector

This intermediate is widely used in:

Drug development projects

Contract research and manufacturing

Bulk pharmaceutical production

Chemical & medicinal research laboratories

Its versatility and purity make it suitable across multiple production scales.

Conclusion

1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole (CAS 575452-22-1) plays a crucial role in the production of Ruxolitinib, contributing to the creation of a highly effective therapeutic molecule. VidgasTech continues to support the global pharmaceutical industry with high-quality intermediates, reliable services, and customer-centric solutions.

Introduction

In the pharmaceutical industry, the importance of high-quality intermediates cannot be overstated — they form the foundation for producing life-saving drugs. One such crucial compound is 4-Fluoro-2-Methoxy-5-Nitroaniline (CAS No: 1075705-01-9), a key Osimertinib intermediate. This compound plays a vital role in the synthesis of Osimertinib, a third-generation EGFR inhibitor used to treat advanced stages of non-small cell lung cancer (NSCLC).

Among the reliable global suppliers, VidgasTech stands out as a trusted name known for manufacturing and delivering premium-grade pharmaceutical intermediates with consistent quality and purity.

Understanding 4-Fluoro-2-Methoxy-5-Nitroaniline

4-Fluoro-2-Methoxy-5-Nitroaniline is a fine chemical compound with the molecular formula C7H7FN2O3 and molecular weight 186.14 g/mol. It appears as a light yellow to brown crystalline powder and is highly valued for its role in organic synthesis, particularly in the pharmaceutical sector.

As a critical intermediate in Osimertinib synthesis, this compound contributes to the development of targeted cancer therapies that inhibit specific mutations in EGFR genes, improving the survival rates and treatment outcomes for cancer patients.

Role in Osimertinib Intermediates

Osimertinib has revolutionized the treatment of lung cancer, especially in patients resistant to earlier generations of EGFR inhibitors. The synthesis process of Osimertinib involves several key intermediates — one of the most important being 4-Fluoro-2-Methoxy-5-Nitroaniline. High-quality intermediates ensure that the final drug maintains its purity, efficacy, and safety profile, which is why sourcing this compound from a trusted manufacturer is essential.

Why Choose VidgasTech

VidgasTech is an established manufacturer and supplier of pharmaceutical intermediates, API intermediates, and fine chemicals for research and industrial applications.

Here’s what makes VidgasTech a reliable partner:

✅ Superior Purity: Every batch is produced and tested to meet international standards. ✅ Cutting-edge Manufacturing: Advanced infrastructure ensures high yield and consistent performance. ✅ Custom Synthesis: Tailored solutions based on customer specifications. ✅ Global Delivery: Fast and secure worldwide logistics. ✅ Commitment to Quality: Backed by a skilled technical team and strict quality assurance practices.

Applications

Pharmaceutical Intermediate for Osimertinib

Research and Development in Medicinal Chemistry

Fine Chemical Synthesis

About VidgasTech

VidgasTech is a leading pharmaceutical intermediate manufacturer in India, specializing in Osimertinib intermediates, API intermediates, and specialty chemicals. The company focuses on delivering reliable, high-quality chemical solutions to the global pharmaceutical industry.

5-Bromo Uracil (5-BU) is a chemical compound widely used in genetic engineering and molecular biology. It is known for its ability to replace thymine in DNA, making it an essential tool in mutation research and DNA replication studies. In this article, Vidgastech explores the properties, applications, and importance of 5-Bromo Uracil in modern science.

What is 5-Bromo Uracil?

5-Bromo Uracil is a synthetic analog of thymine, one of the four nucleobases in DNA. Its chemical structure allows it to integrate into DNA in place of thymine during replication. Unlike thymine, however, 5-BU has the unique ability to pair with both adenine and guanine, making it a powerful mutagenic agent.

Chemical Formula: C₄H₃BrN₂O₂

Molar Mass: 190.99 g/mol

Classification: Pyrimidine analog

Appearance: White crystalline powder

How Does It Work?

The key to 5-Bromo Uracil’s effectiveness lies in tautomerism. In one form, it pairs with adenine just like thymine does. But in its alternate form, it pairs with guanine. This mispairing causes transition mutations, which are crucial for genetic experiments and research into DNA replication errors.

Major Applications of 5-Bromo Uracil

1. Inducing Mutations for Research

5-BU is used to intentionally induce point mutations in DNA, helping researchers study genetic sequences, gene function, and mutation rates.

2. Cancer and Drug Research

Because of its DNA-interfering properties, 5-Bromo Uracil is often used in cancer studies to observe how cancer cells replicate and respond to DNA-altering compounds.

3. Studying DNA Repair Mechanisms

By incorporating 5-BU into DNA, scientists can examine how well cells detect and repair errors—a process critical to preventing genetic disorders.

4. Radiation Sensitivity Testing

Cells containing 5-BU show increased sensitivity to UV and ionizing radiation, aiding in radiation biology research.

Safety and Handling

5-Bromo Uracil should be handled with care, especially in lab environments. Protective gloves, lab coats, and proper ventilation are recommended due to its mutagenic nature.

Conclusion