In Skylanders: Lost Islands, Dr. Krankcase appears as a trappable villain that can arrive in the player's kingdom. Upon being trapped, he will help the player by halving the cost of powering Elemental Sanctuaries.

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In the Light in the Dark comic, during the Annual Mabu Meander, Dr. Krankcase attempted to enter the race and win despite being in a clear advantage over the Mabu children. Knight Mare quickly entered the race as well and chased after the villain. Despite his efforts to slow the Dark Trap Master down, Dr. Krankcase was knocked into a tree by Knight Mare, allowing the Mabu to race fairly.

Before the events of Imaginators, Dr. Krankcase was responsible for the creation of Boom Bloom.

Seen above: The icon for Dr. Krankcase's Caustic Effect upgrade from his For the Greater Goo'd upgrade path

In Imaginators, Dr. Krankcase has kept his spider leg spin though with tweaked speed, and his toxic goo can now be shot from two guns much faster; he can also summon robotic hat minions to attack alongside him.

In Skylanders: Battlecast, Dr. Krankcase's abilities are augmented with a mechanic to gradually worsen an enemy's health. His green goo now prevents healing, his Woodstein seeks out weak enemies, and he can create a Smog Machine relic whose intoxicating fumes gradually decrease max health on the enemy side. He can also drop a Barrel o' Laughs on enemies to release a Tech spell's energy as damage. Jawbreaker, also in the card game, has the ability to summon him from a trap Relic, allowing Krankcase to attack enemies for as many ranks they have.

Seen above: Drobot's Core Skylander icon