Mar 5, 2019
Saccharide
n. Any of a series of compounds of carbon, hydrogen, and oxygen in which the atoms of the latter two elements are in the ratio of 2:1, especially those containing the group C6H10O5.
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Saccharide
n. Any of a series of compounds of carbon, hydrogen, and oxygen in which the atoms of the latter two elements are in the ratio of 2:1, especially those containing the group C6H10O5.
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Glycolyse
Anaerober Abbau von Glucose zu Pyruvat
Bilanz: Glc + 2 NAD+ + 2 (ADP + Pi) -> 2 Pyr + 2 NADH/H+ + 2 ATP + 2 H2O
Investitionsphase:
Phosphorylierung von Glucose zu Glc6P durch Hexokinase*
Isomerisierung zu Fru6P durch Glc6P-Isomerase
Phosphorylierung zu Fru16bP durch Phosphofructokinase*
Spaltung durch Aldolase zu DHAP und GA3P
Umwandlung von DHAP in GA3P durch Triosephosphat-Isomerase
Amortisierungsphase:
NAD+-abh. phosphorylierende Oxidation zu 13bPGlycerat
ATP-Gewinn durch Phosphoglycerat-Kinase zu 3PGlycerat
Umlagerung zu 2PGlycerat durch Phosphoglycerat-Mutase
Dehydratisierung zu PEP durch Enolase
ATP-Gewinn durch Pyruvat-Kinase zu Pyruvat
Gegenläufige Regulation der Glycolyse und Gluconeogenese
Zusammenhängende Stoffwechselwege:
Glc liefernd: Glycogenolyse, Transport von Glucose, Gluconeogenese
Intermediate liefernd: Pentosephosphatweg, Einführung weiterer Zucker, Glycerinabbau
Intermediate benötigend: Acylglyceridbildung, Serin- und Glycinbildung
Pyr benötigend: Milchsäuregärung, Alkoholische Gärung, Acetyl-CoA-Bildung, Alaninstoffwechsel
Nebenwege: Rapoport-Luebering-Zyklus