Bridge of Sight
Sight depends on the many different cell types of the eye'sΒ retinaΒ all functioning correctly in the right place. TheΒ photoreceptor cellsΒ (PRC) that respond to the light and transduce that response to the brain are constantly being degraded and renewed. Ingestion of the degraded material is managed by theΒ retinal pigment epitheliumΒ (RPE), normally in close contact with PRC. This study now shows that RPE continue to perform their function in eye diseases where PRC and RPE are separated, thanks to the ability of RPE to reach outΒ pseudopodiaΒ (membrane extensions) across that gap. Shown is aΒ 3D reconstructionΒ of an RPE pseudopod (light green) bridging the expanded sub-retinal space in a mouse model of a retinal degenerative disease.
Read the published research articleΒ here
Image from work by Tylor R. Lewis and colleagues
Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA
Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
Published in Journal of Clinical Investigation, April 2026
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