#restoring active memory

Moringa oleifera is one the tropical trees with rich antioxidants. Various research projects have been conducted to study the effect of the moringa oliefera extract on the conducted studies using rats as the models. In the study, rat model of Alzheimer's disease was prepared by intra cerebro-ventricular infusion of colchicines. Colchicines are a microtubule-disrupting agent that produces marked destruction of hippocampus granule cells, mossy fibers and septo-hippocampal pathways. Colchicines-induced cognitive impairment has been established as an animal model of sporadic dementia of Alzheimer’s type.

This caused a decrease in the learning behavior in the rat models as there was decrease in correct choices in daily trials as this was notified. It has been found to increase the latency period along with a decrease in Super Oxide Dismutase (SOD) level and Catalase. This has elevated the Lipid Per Oxidase (LPO) activity. Super Oxidase Dismutase is an enzyme associated with copper, zinc, manganese, and iron by body cells. It can break down the super oxide free radicals.     

Out of 10 daily trials, the correct choices decreased and the latency period increased significantly. The inter relation between behavioral and antioxidant activity revealed higher levels. Colchicines impaired memory was observed by measuring learning and memory behavior in RAM task. This may be accomplished by removing cell defending enzymes such as SOD and Catalase. This has been found to increase the LPO activity.

After giving moringa oleifera leaves 250 mg /Kgb.w to the rats for 14 days it was identified that it helped to improve memory power. This was observed from Restoring Activity Memory performance by increasing the correct choices in daily trials and decreasing the latency time. Antioxidant property of moringa oleifera leaves have been verified to contribute to a great extent for increase in memory power. Moringa dried leaf powder was found to have twice the nutrients than the fresh leaves. Increased SOD and Catalase activity and decreased LPO activity has been reponsible for activity of this powder.