Co2 (carbon dioxide) - 3 ways
1) dissolved in plasma (10%)
2) as hco3 (bicarbonate) (70%)
a) happens both inside the red blood cell and in plasma.
i) co2 binds with h2o (water) to make h2co3 (carbonic acid) which is unstable so it breaks itself into H (hydrogen) and hco3 (bicarbonate)
ii) slower process in plasma compared to in rbc because rbc has carbonic anhydrase enzyme to speed it up
iii) the hco3 inside the rbc needs to shift outside into the plasma, it shifts through a transport channel with the help of the protein Band 3. In exchange, Cl (chloride) shifts inside. This is to keep electrochemical neutrality.
iv) excess H binds with Hb (hemoglobin) making HHb (deoxyhemoglobin). Too little H -> high pH = alkalosis. Too much H -> low pH = acidosis
3) as HbCo2 carbaminohemoglobin (20%)
a) co2 binds with Hb. It binds to the globin part
1) dissolved in plasma (2%)
2) bound to hemoglobin HbO2 (98%)
a) o2 binds to the heme part. The heme has iron in it and that what o2 is binding to