#quarterfinals

"They switch places at ten years old so Thom can learn magic and Alanna can become a knight"

She's the titular Girl Genius, which is a good start. In the comic, mad science is genetic and called the Spark; she's the latest in a long line of of powerful, mostly evil Sparks who terrorized Europa for centuries, until her father and uncle became heroes instead. She's a bit in between the two extremes. Some of her greatest hits include: building a small army of self-replicating robots, briefly killing one of her romantic interests in order to cure him of a terminal illness (he thought it was a brilliant idea), repeating the procedure on herself, nearly blowing up after glimpsing the fabric of the universe, repairing the sentient castle at the heart of her town, frequently having to shuffle around brains that end up in the wrong body (they are usually happier afterwards), building a giant robot in order to ask the Godqueen of England to dance, and making coffee. At this time in the comic, she recently rescued her town from being frozen in time and is working to kill a horror from another dimension.