#mcad

1/24/26

This resource is intended as an introductory primer for primary care clinicians who are beginning to consider whether a patient’s component conditions are part of a larger constellation. The relationship between Autism/ADHD and these conditions is well-established in the literature, and is linked throughout this resource. There is also literature identifying sub-clusters amongst these conditions, including hypermobility, dysautonomia, chronic pain, neurodivergence (Csecs et al 2022); hypermobility, dysautonomia, GI, allergic conditions (Brooks et al 2021), and hypermobility, dysautonomia,mast cell dysfunction (Wang et al 2021). We expect that this resource may be useful for many of your non-Autistic/ADHD patients. The main goals of this introductory resource is to emphasize the connections between these medical conditions, and explain how these connections may impact management (and hinder clinical improvement). 1. For patients with this constellation who are not improving, consider screening for the rest of the constellation. 2. In the Management table, we think the most important part is the “Cautionary Notes” column. These may reveal unrecognized barriers to clinical improvement. Many of the standard treatments for some components of the constellation make the other component conditions worse

if you developed sudden, unpredictable allergy-like symptoms after a covid infection there is a strong chance that you developed MCAS. MCAS is treatable, you just need to see an allergist/immunologist about it. I made a post with more info here.

Keep ICE out of Minneapolis.