RNA Framework v2.6.7 (minor) released
This release fixes an unexpected behavior in rf-fold causing pseudoknots to not being reported under specific circumstances.
Moreover, this release introduces a new feature in the rf-norm tool. Now, sliding-window normalization can be performed using dynamic windows. This feature is particularly useful when analyzing RNA probing experiments performed using base-specific reagents (e.g. DMS, CMCT, Kethoxal, etc.).
Using dynamic windows, the size of the normalization window is dynamically adjusted to include the required number of reactive bases (e.g. A/C residues for DMS-modified RNA molecules, as in the above example). This allows minimizing overestimation artifacts caused by the uneven distribution of reactive bases along the analyzed transcript.
For more information, please refer to the documentation.
