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James Harrison, who according to the Australian Red Cross was the world's most prolific blood and plasma donor, has died at age 88.
He was known as "the man with the golden arm." James Harrison, who according to theĀ Australian Red CrossĀ was the world's most prolific blood and plasma donor, has died at age 88. Harrison's plasma contained the rare antibodyĀ Anti-D,Ā also known asĀ Rhesus D antibody, which is used to make the medication given to mothersĀ whose blood is at risk of attacking their fetuses.Ā He donated plasma 1,173Ā times and isĀ credited with saving 2.4 million Australian babies, according to the Red Cross. The formerĀ Guinness World Record holderĀ died in his sleep on Feb. 17.
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By donating blood over 1,100 times, James Harrison helped develop Anti-D, a life-saving treatment for newborns at risk of Rhesus disease
James Harrison, one of my personal heroes, passed away today at 88. Over 2 million babies saved šš
Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helpin
Australia's most prolific blood and plasma donor, James Harrison, has died at age 88. Known as the "Man with the Golden Arm," Harrison is credited with saving the lives of 2.4 million babies over the course of more than half a century.
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Harrison's plasma contained a rare and precious antibody called anti-D, which was discovered in the mid-1960s. It is used in medications to prevent haemolytic disease of the fetus and newborn (HDFN) ā also known as rhesus disease ā a potentially fatal disease that occurs when a pregnant person's blood is incompatible with that of their unborn baby, prompting their immune system to attack it.

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James Harrison, Whose Antibodies Helped Millions, Dies at 88
This was published on March 4th
James Harrison did not much care for needles. Whenever he donated plasma, he would look away as the tip went into his arm.
But Mr. Harrison was one of the most prolific donors in history, extending his arm 1,173 times.Ā He may have also been one of the most important: Scientists used a rare antibody in his plasma to make a medication that helped protect an estimated 2.4 million babies in Australia from possible disease or death, medical experts say.
āHe just kept going and going and going,ā his grandson Jarrod Mellowship said in an interview on Monday. āHe didnāt feel like he had to do it. He just wanted to do it.ā
Mr. Harrison ā who was affectionately known as āThe Man with the Golden Armā ā died in his sleep on Feb. 17 at a nursing home about an hourās drive north of his regular donation center in Sydney, Mr. Mellowship said. He was 88.
Mr. Harrisonās plasma contained the rare antibody anti-D. Scientists used it to make a medication for pregnant mothers whose immune systems could attack their fetusesā red blood cells,Ā according to Australian Red Cross Lifeblood.
Anti-D helps protect against problems that can occur when babies and mothers have different blood types, most often if the fetus is āpositiveā and the mother is ānegative,āĀ according to the Cleveland Clinic. (The positive and negative signs are calledĀ the Rhesus factor, or Rh factor.)
In such cases, a motherās immune system might react to the fetus as if it were a foreign threat. That can lead babies to develop a dangerous and potentially fatal condition, hemolytic disease of the fetus and newborn, which can causeĀ anemia and jaundice.
The condition is uncommon: Only about 276 out of 100,000 live births have complications related to this type of blood incompatibility, the Cleveland Clinic said.
But doctors cannot predict whether such an incompatibility will lead to serious problems. So, in Australia, the practice is to offer the medication to all pregnant women with negative antibodies as a preventative measure.
In Australia, thatās about 17 percent of the population, or about 45,000 women a year. In the United States, itās about 15 percent, according to the Cleveland Clinic.
In Australia, scientists from the Walter and Eliza Hall Institute of Medical Research in Melbourne are working to create a synthetic version of the drug using what some have called āJames in a Jar,ā anĀ antibody that can be made in a lab.
But for now, human donors are essential: The anti-D shots are made with donated plasma, and Mr. Harrison was one of about 200 donors among the 27 million people in Australia, Lifeblood said.
āIt wasnāt one big heroic act,ā Jemma Falkenmire, a spokeswoman for Lifeblood, said in an interview as she reflected on Mr. Harrisonās 64 years of donations, from 1954 to 2018. āIt was just a lifetime of being there and doing these small acts of good bit by bit.ā
Mr. Harrison sometimes met some of the women he helped, although most were strangers.
But two he knew well indeed. His daughter, Tracey Mellowship, received an anti-D injection made with Mr. Harrisonās plasma. So did his granddaughter-in-law, Rebecca Mellowship, who is married to Mr. Mellowship.
āIt was special that I received Dadās anti-D,ā Tracey Mellowship, 58, wrote in an email.
But his rare antibodies were only part of the puzzle. Mr. Harrisonās commitment was key. He donated about every two weeks from ages 18 to 81, first his blood and then his plasma.
Vacations did not stop him: He would stop in clinics across Australia when he and his wife, Barbara Harrison, traveled in their camper van. She was a prolific blood donor, too.
Neither did old age: He rode the train for more than an hour each way to get from his home outside Sydney to his regular donation center.
And he never missed an appointment, said Ms. Falkenmire, the Lifeblood spokeswoman, who talked to him during donations.
Partly, she said, they just enjoyed chatting. But he also welcomed the distraction. āHe was petrified of needles,ā she said. āHe hated them.ā
Mr. Harrison knew the importance of his work firsthand. At 14, he needed a lot of blood transfusions during a major lung surgery. The experience inspired him to donate and encourage others to donate, too.
āHe would walk up to people who were donating for the first time and congratulate them, and tell them they were important and special,ā Ms. Falkenmire said, āwithout revealing anything about his own donations.ā
James Christopher Harrison was born on Dec. 27, 1936, in Junee, a small town in New South Wales, to Peggy and Reginald Harrison.
After he recovered from lung surgery, he met his future wife, Barbara Lindbeck, when he was a teenager. She was a teacher who died in 2005. He worked as a clerk in the regional railway authority. HeĀ received the Medal of the Order of Australia in 1999Ā for his donations.
In addition to his grandson Jarrod, Mr. Harrison is survived by his daughter, Tracey; another grandson, Scott Mellowship; and four great-grandchildren.
And also, maybe, 2.4 million babies ā which Mr. Harrison never quite knew how to comprehend.
āSaving one baby is good,ā he said after his final donation in 2018. āSaving two million is hard to get your head around, but if they claim thatās what it is, Iām glad to have done it.ā
Mr. Harrisonās wish, he liked to say, was that people would keep donating. Maybe even more than he did, Jarrod Mellowship said, ābecause then it means the worldās going in the right place.ā
The man with a golden arm
The Man With The Golden Armā-the most prolific donor with the rare blood type that can save the lives of pregnant women and their babies with Rhesus Disease. And the inspiration for Bobbyās unique ability to help a large number of people with his blood.
Known as the 'man with the golden arm', James Harrison's blood contained a rare antibody that saved millions of lives.