Chronic Illness: Cristallo, Rabies, Erick, Semmelweis, Barbara

Cristallo was born prematurely, with an added condition that makes her physically fragile. As seen in the game, she needs a life-support system to maintain her health when she’s outside. It’s also implied that her condition may be a recurrent cancer, as her arcane abilities are tied to a machine that provides cobalt therapy, a known advancement in radiotherapy in the post-WWII era.

In Sotheby’s anecdote, it’s been noted that Cristallo needs extra accommodations to her room, and it’s crucial that the electricity is kept running; she would risk having episodes like seizures otherwise.

Rabies is an odd case. In his stories, it’s stated that Adam Miłosz cured Alicia of rabies through unknown means, at the cost of contracting the disease himself. However, instead of the virus being acute and guaranteed to be fatal, it became a chronic illness to Rabies due to the abundance and use of arcanum.

Since the rabies virus attacks the brain, his cognitive capabilities and ability to recall things before the present had been impaired, making him rather docile and animal-like in nature as a result.

As revealed in her anecdote, Erick has a hereditary blood condition that came with her arcane skill. While her arcane skill grants her insane strength, overusing it will accelerate the effects of her blood condition to the point that it can turn fatal. To prevent this, she also inherited an armband from her grandfather, Harald. The armband suppresses Erick’s ability to use arcane skills, but by extension it also prevents her condition getting worse.

Semmelweis’ journey in the roguelike has been very clear that she suffers from the Beyond disease, a parasitic and incurable disease that mainly affects the brain by heightened hallucinatory symptoms paired with vampiric-like symptoms. The disease has a high fatality rate, but survivors tend to be granted abilities and urges equivalent to that of a vampire.

Semmelweis keeps her symptoms at bay through Lorelei’s arcane skill, and maintains her urges with sweets such as chocolate. While the Beyond Disease is most known for being passed on via contact, (e.g. biting) it has also been found to be genetically carried by some people.

(Bonus mention: Valentina is also a canon survivor of the Beyond Disease, having become a full vampiric-like being. She was the one that bit and infected Semmelweis)

Being born as a cross of 3 different beings, Barbara was born with a delicate body and she suffered a multitude of conditions growing up. Among them, asthma and insomnia were the most prominent. These conditions were incredibly debilitating for her growing up, and they continue to persist til her adulthood. Because of these medical scares (and her instinctive tendencies), she also has anxiety. For this—and strangely enough—her conditions can be alleviated with stuffed toys and the country music that she keeps on her at all times, much to her chagrin.

Amputees: Shamane & Willow

Shamane lost his left arm as a punishment for his previous failures. But after having lived without it for 20 years, the lack of it doesn’t bother him anymore. In fact, he finds pride in his loss, claiming it as a “token of bravery.”

Prior to the events of 1.3, he crafted his prosthetic arm as a means to avoid scaring kids. In his I2, we see that he was provided with a more modern prosthetic, likely provided by Laplace.

Willow is mainly characterised by her ability to perform in floor gymnastics having a prosthetic leg. Even when she lost her leg when she was younger, it didn’t stop her from performing to the best of her capabilities and reworking her skills in floor.

Blindness: Urd, Ms. Radio, Argus

Urd, despite her mysterious presence in the story, is most notable for her blindness. Throughout all her appearances, she's always found with a covering over her eyes, and has been referred to as the “blind woman” throughout the game many times even prior to her reveal. She also has recurring partial amnesia, with the “Storm” being the main cause of it.

She still chooses to travel across cities despite it, documenting her travels and insights about each place as the “Friend From Afar.”

Despite all the awakened lacking any eyes, Ms. Radio is the only character that has explicitly stated that she does not have any eyesight. She uses her body vessel and the radiowaves to be able to sense things around her, and is a generally sensitive entity.

Argus is notable for her vision impairment and partial blindness due to an untreated injury paired with her arcane skill. She struggles to see at nighttime, and has to activate her arcane skill to be able to do work. She tends to use picrasma candies to keep her arcane skill running for as long as possible.

However, Argus will tend to overexert herself and her arcane skill, which can result in her having temporary complete blindness. She refuses to have her injured eye treated nor be provided a prosthetic either.

Others

Mobile Disability - Noire *revised on 25th September 2025

Our diva Noire here is unique for the fact that she is one of the few fictional characters who actively uses a wheelchair in the game. She suffered from a car accident that left her paralyzed from the waist down, and her story explored her interpreting her condition as a "sign" to change her approach in her life and work. She willingly accepted her outcome and decided to refuse treatment, since she believed in that this change—as violent as it was—was a way for her to reevaluate and relearn how to live and to create.

Speech Impediment - Balloon Party

Balloon Party as a child had contracted an illness that caused her to have a persistent high fever. In the end, she awakened her arcane skill this way, with her being able to cough up balloons that can be harmful or a cure to anything. However, it might have also affected her speech because of the physical strain that comes from coughing, it results to Balloon Party’s speech being slowed and having abnormal pauses before she speaks again. 

Burn Scarring - Joe

Being a blacksmith, Joe gained a lot of burn injuries due to his work. He developed his skill over time, but it came at a cost; these scars became a part of him. Considering that Joe very likely never went to get proper treatment due to him growing up less privileged, it’s also likely that these scars crudely healed and can cause some pain. His scars are most prominently seen in his face, but they extend down the left arm and even both his hands, which are bandaged.

Albinism - Windsong

Windsong has indicators that she may have albinism; from her white hair, pale skin, and differently-coloured eyes. It can be assumed that she has Type 1 OCA, which leaves her to have the aforementioned features. There isn’t much beyond that mainly due to this being a popularized headcanon among the fandom, so what other symptoms she might have is open to interpretation.

Honorable Mentions

What is this section? The honorable mentions list is meant as a list for:

-Characters I realized I should've added here but it was too late

-Characters who have some headcanons/insights from other users from both Twitter and Tumblr, and I took it to consideration

I hope you enjoy these ones. :)

Oliver Fog - Depression, Arthritis/Chronic Pain (credited: @space-magician on tumblr)

Early on in childhood, Oliver had been exposed to how the London fog takes a heavy toll on his family and has experienced grief early on due to his father passing away from overexertion. It prompted him to start working as a (greatly desensitized) Fogwalker, feeling an unbearable weight on his shoulders metaphorically and even literally with how he struggles to get up in certain weather conditions. It hints towards him having chronic pain/arthritis due to the intensive nature of his work, as well as depression stemming from his grief.

Loggerhead - Short-Term Memory Loss

Loggerhead has short-term memory loss as an aftereffect of her awakening, causing her to slowly lose memory over the course of 3 days. However, Laplace provided her with a special film that allowed her to maintain her memories for longer.

Last Notes

Of course, these are only the first batch of this list, and I hope you'll have fun reading the next two installments here once linked. :)

Psychologically Disabled Characters

Neurodivergent Characters

As for "dale cow tongue," I think it refers to gasteria, a type of succulent known with the common name "cow's tongue" or "ox tongue." The plant's leaves typically have these little white dots on them, which might be why arcanists called them "dyed pearl grass."

Lastly, the straight-forward ingredients that they spelled out for us. "Jamaican pepper" is allspice and "the hoof of a four-legged beast" is just horse hoof (very understandable because horses are dangerous and their kicks can kill you).

A Knight (hat and hair): One step further, and you will be in close contact with Someone's nose... As long as you can hit Someone's head. (how close is Vertin standing to the AK? Or maybe she was looking for an invisible head to pat.)

Mesmer Jr (Hands) :Compared to the incurable anxiety, these wounds are minor. Oh, watch your distance. (smh Vertin not everyone likes being touched.)

Melania (hat and hair): "Well done. Please keep on." ...Aren't you going to say that? (more headpats but Melania needs vocal praise too.)

Lilya

Clothing and torso:  Feel awesome? Now it's my turn to pet you. (...what is Vertin petting? This is clothing and torso but I'm lost.)

Hat and hair: You should be grateful that I am too lazy to move now. Or you should know that the first-class pilot’s got a first-glass head-butt, too. (Vertin taking advantage of the moment to give headpats. I'm telling you, its a THING)

Leilani (Hands): Shaka brah! Ooh! Do you want a handshake or a high-five, my friend? I'm fine with either! (She’s so wholesome)

Cristallo 

hat and hair: Are you patting my head? The doctor says, this is a reward for good children. Have I done something right? 

Hands and sleeves: Would you like to hold my hands? I could be with you anytime. (Cristallo is weak and frail. The nurses say she could be blown away by a gust of wind. Despite this she says she’ll be with Vertin anytime. To me it reads as Vertin being worried Cristallo will disappear too. Cristallo notices so she offers to hold hands and says she will always be here as a way to comfort her.)

Darley Clatter

Hat and Hair:  Oh ... I can't deny you are really good at patting.

Clothing and Torso: Take a look at my beautiful muscles! I don't need to explain how fabulous I am. Hey, watch out! Rub me in the direction my mane grows.

Bonus Intimacy : Adorable? Ahh? You don't even have a taste! (Vertin pets him and calls him adorable. Darley, don’t let the girlies know. They might end your noble bloodline.)

Pavia (Hat and Hair): Wanna know how many holes I've made on others' heads? No? Then stop it. (What possessed her to give Pavia headpats?)

Dikke (hat and hair): Thou art overstepping my boundaries, arcanist. (I’m guessing Vertin is at it again with the headpats. Dikke smiles when she says this so she isn’t offended. If anything, she seems amused. )

Eternity (hands and sleeves): Go on, try holding it, and feel its temperature rising in your hand… Easy, sweetheart… take it easy, heh heh… (more hand holding but Vertin wasn’t prepared this time)

An-an Lee (hands and sleeves): What? You want a palm reading? (Vertin, why are you like this? Are you randomly touching people's hands?)

Regulus (hands and sleeves): What do you want? I don't have any spare scratch. (I'm sure she knows you're broke since she's your boss. Vertin's just being Vertin at this point.)

Vertin leads Regulus by the hand into her Suitcase in the prologue

Blonney (hands): Interesting! It's been a while since I last met someone who would start with holding hands.

She also holds Blonney's hand as she calms her down during the green lake event.