#ceramide

Stopping Ceramide Damage

This image shows a proximal tubule of the kidney. These tubules are highly metabolically active, their job being to reabsorb water and other vital substances (sodium, glucose and more) back into the blood as well as to secrete waste products. They are also, generally speaking, the most susceptible parts of the kidney when it comes to injury – caused by dehydration, infection, and heart issues, among other things. Urinary ceramides – a type of lipid found in the tubule cell membranes – are early markers of such damage and, it turns out, the cause of it too. The tubule cells are jam packed with mitochondria to meet their sizeable energy requirements and a build-up of ceramides directly impairs mitochondrial morphology (shape) and function. Importantly, when mice were given a ceramide-lowering drug and subjected to kidney-damaging conditions, the animals were protected from renal injury and had near-normal looking kidneys.

Written by Ruth Williams

Image by Luis Cedeño-Rosario, from work by Rebekah J. Nicholson & Luis Cedeño-Rosario and colleagues

Department of Nutrition and Integrative Physiology, University of Utah College of Health, Salt Lake City, UT, USA

Image copyright held by the original authors

Research published in Cell Metabolism, January 2026

A ceramide-based balm / cream / lotion - I use one from Physiogel.

Pure aloe vera gel - Bon Organics. It's amazing.

Hylaurnic acid serum - currently using one from Chemists at Play. It's a new brand.

Oil cleanser - I have been using Bioderma Atoderm Huile de Douche for past 3 months and I have nothing but praise for this.

Eye creams can be a great product to include in your skincare routine. With so many different eye creams available it can be hard to pick the perfect formula, especially since many eye creams are almost the same as your regular face cream and don’t provide any additional benefits. Here we have rounded up the 5 best eye creams that combine deep hydration action with clinical, scientifically proven ingredients.

CeraVe Eye Repair Cream

The CeraVe line is targeted towards people with sensitive skin and eczema. If you want good benefits and clinical, dermatologist skincare in an eye cream without irritating the eyes, Cerave is a good option. The CeraVe Eye Cream contains three ceramides to strengthen the skin and help prevent damage. It also has hyaluronic acid to hydrate and plump skin. The formula is very lightweight and a great product for anyone who is usually sensitive to eye creams.

First Aid Beauty FAB Skin Lab Retinol Eye Cream with Triple Hyaluronic Acid

If you have dark circles, and also want hydration and anti-aging properties the First Aid Beauty Retinol Eye cream is ideal. This eye cream contains micro retinol to help combat wrinkles, discolouration, and fine lines, the products retinol works over time to increase cell turn over and collagen production. The retinol is combined with a large amount of hyaluronic acid to hydrate the skin.

made a visual index of things I want, have, or plan to get

This was a fun, quick and easy PM regimen, which sometimes, is exactly what you need in life.

I really like The Body Shop’s seaweed skincare line—it does a good job of purifying my pores and calming down spots without overdrying me, which is basically the gold standard for acne-prone combination skin. I wanted to do a somewhat sea-themed regimen, so I followed the cleanser and toner with the SkinFood Jellyfish Marine Hydrogel Mask, which was super moisturizing and soothing—I left it on for nearly an hour and it was still soaking in when I finally pulled it off and patted in the rest.

Un danno grave alla funzionalità renale a breve termine, noto come danno renale acuto (IRA), può essere fatale e aumentare il rischio di malattia renale cronica irreversibile. Può essere scatenato da fattori di stress che vanno dalla sepsi all’intervento chirurgico al cuore e colpisce oltre la metà dei pazienti in terapia intensiva. Attualmente non esistono farmaci per il trattamento dell’IRA.…