#carnivorous

The samples of the study included three species of mammals, including: ten female dogs, five women and one Holstein Friesian cow. All of them had a lump on their mammary glands. The study aimed to determine the susceptibility of these species to mammary tumors. Case history and clinical findings were recorded for each individual from whom specimens were collected. The biopsies were subjected to H & E staining for histopathological examination as well as immunohistochemistry technique for BRCA1and Ki67 level determination. On histopathological slides, 8 out of 10 of dogs showed carcinoma, which was classified into adeno, lipo, solid or inflammatory, while the other two cases had benign adenoids. The cases of women revealed different patterns: one had ductal carcinoma in situ, another one with lobular carcinoma in situ, two cases had fibroadenoma and the last case showed a cyst. In the cow, the masses were founded in the teat of the left front quarter of the mammary gland with enlargement of local and sub scapular lymph nodes. In conclusion, female carnivores represented by female dogs were more sensitive to catch a mammary tumor than omnivores represented by women, while herbivores represented by a cow were the most resistant. Therefore, these data recommend performing more studies that focus on the variability among animal species in order to reduce the incidence of mammary tumors in mammals especially humans and dogs.