#cardiomyapathy

Variety Upon Variety

Titin, the largest protein produced in the body, is a giant spring-like protein found in muscle cells, including those of the heart (pictured). There are multiple versions of titin, and their production is regulated, at least in part, by splicing factor (cutting the RNA transcript to make different sized versions of the same protein) RBM20 (coloured blue). In the infant mammalian heart, for example, most titin is long and elastic, while in older mammals RBM20 activity leads to shorter stiffer versions of the protein. Aberrant production of RBM20 has been linked to certain cardiomyopathies, suggesting its inhibition in these disorders could be clinically beneficial. Interestingly, new research in rodent and human samples reveals RBM20 itself also has multiple versions, and their production is influenced by developmental stage and disease. The findings suggest regulation of heart muscle flexibility is much more complex than previously thought and that any therapies targeting RBM20 might need fine tuning to pinpoint specific versions of the factor.

Written by Ruth Williams

Image from work by Michael H. Radke, Victor Badillo Lisakowski and Stefan Meinke, and colleagues

Translational Cardiology and Functional Genomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, May 2026

𝖔𝖓𝖊 𝖓𝖎𝖌𝖍𝖙 𝕴 𝖜𝖆𝖘 𝖇𝖔𝖗𝖊𝖉 𝖎𝖓 𝖇𝖊𝖉 【&】 𝖘𝖙𝖆𝖑𝖐𝖊𝖉 𝖞𝖔𝖚 𝖔𝖓 𝖙𝖍𝖊 𝖎𝖓𝖙𝖊𝖗𝖓𝖊𝖙 𝖎𝖙'𝖘 𝖋𝖊𝖒𝖎𝖓𝖎𝖓𝖊 𝖎𝖓𝖙𝖚𝖎𝖙𝖎𝖔𝖓 - 𝖈 𝖆𝖚𝖘𝖊 𝕴 𝖆𝖑𝖜𝖆𝖞𝖘 𝖍𝖆𝖉 𝖆 𝖛𝖎𝖘𝖎𝖔𝖓 𝖔𝖋 𝖚𝖘 𝖘𝖙𝖆𝖓𝖉𝖎𝖓𝖌 𝖑𝖎𝖐𝖊 𝖙𝖍𝖎𝖘

˚₊‧꒰ა 🐬 💿 🌊 ໒꒱ ‧₊˚ -> HANDS AUTOMATICALLY .. come to cover her eyes. ❝ why are your pants coming off ? ❞ she questioned as her whole body turned around away from him , facing back out into the hallway. she could feel the blush spreading across her cheeks. the bathroom was small. but it wasn't too small. she wasn't crowding kelly. ❝ i - uh - brought you a spare shirt. ❞ she hadn't meant to spill the wine. she had just been a little too enthusiastic about what she was talking about. she didn't think she had gotten it on his pants as well. in one hand ( which was still covering her eyes ) was a larger plain white t-shirt. it was hers. she just hated wearing pants to bed. before she held it out back towards him.

Send "Stop talking" for your muse to shut mine up by kissing them Alternatively send "Mmph!" for my muse to be the one to interrupt yours with a kiss.

SHE WAS EXPLAINING THE WAY THE FIELD TRIAGE HAD WORKED IN AFGHANISTAN — lips were on hers , hard and rough , and arms had come around her . It was dizzying , and she hadn't been kissed in ages , not since James . Even then his kisses were sloppy and were meant for him . It took a minute for Igraine to remember , she wasn't with one of the men she knew well .

Her hand lifted to his face , searching for his cheek before she pulled back and made contact, an alarming slap, before stumbling back. ❝ What I had to say on triage was important , and I . . . don't kiss random men . ❞ She quickly wiped her lips with the back of her hand , took another look at him before storming out of the office in search of Weylen or Jack .

Who were they hiring around here ?

★ ⋆ “She only wants you because you are mine. If I loved you less, I'd make you rinse out with bleach."