It’s hard when the think keeping you afloat and alive is guilt and not just wanting to live
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It’s hard when the think keeping you afloat and alive is guilt and not just wanting to live
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odyssey obsessed and sometimes depressed :)
having a personality disorder or bipolar feels like im a werewolf. im so angry for no reason, i had a mental breakdown, was completely fine for 2 weeks, now im insane again.
The urge to be super depresso espresso emo is strong.
Anya is live and ready to show you everything. Watch her strip, dance, and perform exclusive shows just for you. Interact in real-time and make your fantasies come true.
Free to watch • No registration required • HD streaming
I have a disabled son. I have a mental health condition. I have an autoimmune condition. I have a spontaneously formed benign liver lesion. I was in a car accident and have 4 bulging discs.
I cannot change these things like I cannot add an inch to my height. I cannot change my past just like I cannot make the earth or sun stand still.
I make peace everyday with my life because I choose to. I dont have the luxury of playing the Blame Game with God. My life is what it is. I wake up everyday knowing my son will spend his days in a facility after age 22. Thats in 7 years. No one is helping me solve for that. The isolation on this path is crippling. Yet I get up every morning. Because I make a choice.
I am not going to bargain with a God whose love is conditional. Im not going to bargain with either of you for your love. If I become the picture of perfect health it doesn't mean Im godly.
Stop.
I fear it may be that time... again 😑
Abstract— There is a large group of bacterial FtsZ inhibitors, the biological activity of which has been confirmed biochemically. However, t
Abstract— There is a large group of bacterial FtsZ inhibitors, the biological activity of which has been confirmed biochemically. However, the sites of protein-ligand interaction for most of them remain unknown, significantly complicating the further search and combinatorial design of FtsZ inhibitors. This study presents the results of bioinformatic analysis of bacterial FtsZ effectors targeting sites of 4-hydroxycoumarin binding (BP1 and BP2). New data based on original results of pharmacophore screening, chemoinformatics, molecular docking, molecular dynamics simulations, AI-predictions, etc., are presented. The object of the study was a combined library of 379 compounds, formed based on revision of the structural database RCSB Protein Data Bank and biochemically proven FtsZ effectors from ChEMBL. Based on the results of a comprehensive study, 39 compounds were selected, of which 28 were identified as effectors of the sites BP1 and BP2, and another 11 as specific effectors of the site BP2 located in the BP2/IDC superpocket.