#boswellia

AS472 .C216 v. 9

Boswellia is an Ayurvedic spice. It promotes breathing and oral health, improves digestion, increases immunity, maintains skin health, and reduce inflammation.

"[C]onsumers have to ask themselves: Are we willing to lose frankincense in a few generations? “We’ve loved frankincense for a long time,” she says. "What I don’t want to see is that we love these trees to death.”

Frankincense tears. . . For a few years I was getting my frankincense directly from a family in Yemen, who were harvesting it from trees where they lived. It was the best frankincense in the world, heady and rich in fragrance and nearly miraculous as a remedy for pain and inflammation. The stuff of legend, the same as the Queen of Sheba brought to Solomon. But the political situation there went from bad to worse, and I haven’t heard from the family or been able to contact them in well over a year now. These are the last few grains of frankincense i have from them. I hope they are safe, wherever they are. Millions of people have been displaced from their homes, died in acts of war or died from disease spawned by the societal collapse. I hope that Yemen will see a better tomorrow, where the tears of sorrow can stop and the tears of frankincense can flow again. . . . . . . . . . #herbalmedicine #boswellia #frankincense #yemen #اليَمَن #عدن

The resin of Boswellia species has been used as incense in religious and cultural ceremonies and in medicines since time immemorial. Boswellia serrata (Salai/Salai guggul), is a moderate to large sized branching tree of family Burseraceae (Genus Boswellia), grows in dry mountainous regions of India, Northern Africa and Middle East. Oleo gum-resin is tapped from the incision made on the trunk of the tree and is then stored in specially made bamboo basket for removal of oil content and getting the resin solidified. After processing, the gum-resin is then graded according to its flavour, colour, shape and size. In India, the States of Andhra Pradesh, Gujarat, Madhya Pradesh, Jharkhand and Chhattisgarh are the main source of Boswellia serrata. Regionally, it is also known by different names. The oleo gum-resins contain 30-60% resin, 5-10% essential oils, which are soluble in the organic solvents, and the rest is made up of polysaccharides. Gum-resin extracts of Boswellia serrata have been traditionally used in folk medicine for centuries to treat various chronic inflammatory diseases. The resinous part of Boswellia serrata possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids and four major pentacyclic triterpenic acids i.e. β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid, responsible for inhibition of pro-inflammatory enzymes. Out of these four boswellic acids, acetyl-11-keto-β-boswellic acid is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation.

Colorectal cancer is one of the most common causes of cancer-associated mortality worldwide, but it is truly a preventable disease. Both curcumin and boswellic acids are well-established dietary botanicals with potent antitumorigenic properties that have been shown to modulate multiple oncogenic pathways. Recent data suggest that the chemopreventive effects of these botanicals may, in part, be mediated through regulation of key cancer-related microRNAs (miRNA) and their downstream gene targets. Here, we investigated the antitumorigenic effects of curcumin and 3 acetyl-11-keto-β-boswellic acid (AKBA) on modulation of specific cancer-related miRNAs in colorectal cancer cells and validated their protective effects in vivo using a xenograft mouse model. Both curcumin and AKBA inhibited cellular proliferation, induced apoptosis and cell-cycle arrest in colorectal cancer cell lines, and these effects were significantly enhanced with combined treatment. Gene-expression arrays revealed that curcumin and AKBA regulated distinct cancer signaling pathways, including key cell-cycle regulatory genes. Combined bioinformatics and in silico analysis identified apoptosis, proliferation, and cell-cycle regulatory signaling pathways as key modulators of curcumin and AKBA-induced anticancer effects. We discovered that curcumin and AKBA induced upregulation of tumor-suppressive miR-34a and downregulation of miR-27a in colorectal cancer cells. Furthermore, we demonstrated in a mouse xenograft model that both curcumin and AKBA treatments suppressed tumor growth, which corresponded with alterations in the expression of miR-34a and miR-27a, consistent with our in vitro findings. Herein, we provide novel mechanistic evidence for the chemopreventive effects of curcumin and AKBA through regulation of specific miRNAs in colorectal cancer.

#erboristeria_arcobaleno_schio #Boswellia #InfiammazioneCronica #Fitoterapia #MedicinaIntegrata #SaluteNaturale #Benessere #Artrite #IBD #Asma #Dermatologia #Prevenzione #NaturaECura