#acidosis

Gonna start some serious studies.

Have to learn some biochemistry, then start on the pending anatomy portions, then finally donsome physiology.

COPD

Cardiac Arrest

Obstructive airway disease

Paralysis/Polio of respiratory muscles

Respiratory Alkalosis -- increased pH -- decreased PaCO2 -- normal HCO3

Respiratory Acidosis -- decreased pH -- increased PaCO2 -- normal HCO3

Metabolic Alkalosis -- increased pH -- normal PaCO2 -- increased HCO3

Normal acid production in body 

VOLATILE ACIDS: 

Produced by oxidative metabolism of CHO, Fat, Protein 

Average 15000-20000 mmol of CO₂ per day 

Excreted through LUNGS as CO₂ gas 

FIXED ACIDS (1 mEq/kg/day)

 Acids that do not leave solution ,once produced they remain in body fluids until eliminated by kidneys

 Eg: Sulfuric acid, phosphoric acid

 Organic acids 

Are most important fixed acids in the body

generated during catabolism of: amino acids(oxidation of sulfhydryl gps of cystine,methionine) Phospholipids (hydrolysis) and nucleic acids 

Regulation

Buffers 

Moderate changes in pH 

Combine with or release H+, cellular proteins, phosphate ions, haemoglobin, or bicarbonate 

Lungs 

Ventilation = rapid response, corrects 75% of disturbances; can also cause them 

Renal regulation 

Receptor-mediated endocytosis 

Directly by excreting or reabsorbing H+ 

Indirectly by changing in the rate at which HCO3– buffer is reabsorbed or excreted 

Imbalances

Normal pH : 7.35-7.45 

Acidosis  = abnormally low plasma pH - Acidemia: plasma pH < 7.35

Alkalosis = abnormally high plasma pH - Alkalemia: plasma pH > 7.45 

Metabolic acidosis: dietary and metabolic input of H+ exceeds excretion 

Metabolic alkalosis: loss of H+ through excessive vomiting or excessive ingestion of bicarbonate-containing antacids

Repository:  hyperventilation or hypoventilation cause pH to shift when PCO2 changes